The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Tumor microenvironment (TME) is a crucial regulator of tumor progression and cells in the
TME release a number of molecules that are responsible for anaplasticity, invasion …

Removal of the intron from precursor-tRNA (pre-tRNA) is essential in all three kingdoms of
life. In humans, this process is mediated by the tRNA splicing endonuclease (TSEN) …

Abstract Transfer RNA (tRNA)‐derived RNAs (tDRs) are a class of small non‐coding RNAs
that play important roles in different aspects of gene expression. These ubiquitous and …

Throughout bacteria, archaea and eukarya, certain tRNA transcripts contain introns. Pre-
tRNAs with introns require splicing to form the mature anticodon stem loop. In eukaryotes …

Through its role in intron cleavage, tRNA splicing endonuclease (TSEN) plays a critical
function in the maturation of intron-containing pre-tRNAs. The catalytic mechanism and core …

Our understanding of the key players in evolution and of the development of all organisms in
all domains of life has been aided by current knowledge about RNA stem-loop groups, their …

Transfer RNAs (tRNAs) represent the most abundant class of RNA molecules in the cell and
are key players during protein synthesis and cellular homeostasis. Aberrations in the …

Introduction Prunus pedunculata (Prunoideae: Rosaceae), a relic shrub with strong
resistance and multiple application values, is endangered in China. Extensive research had …

The maturation of transfer RNAs requires the splicing of precursor tRNAs by specific
endonucleases. New cryo-electron microscopy studies of the human splicing endonuclease …