As a potentially life threatening side effect, pharmaceutical compounds may trigger cardiac
arrhythmias by impeding the heart's electrical and mechanical function. For this reason, any …

The heart is a hierarchical dynamic system consisting of molecules, cells, and tissues, and
acts as a pump for blood circulation. The pumping function depends critically on the …

The two-variable Bonhoeffer–van der Pol oscillator, which is equivalent to the FitzHugh–
Nagumo model, can be represented by a natural circuit, ie, a circuit consisting only of simple …

In our previous studies (Inaba and Kousaka,(2020); Inaba and Tsubone,(2020)), we
discovered bifurcation structures represented by nested mixed-mode oscillations (MMOs) …

In previous works (Inaba and Kousaka, 2020; Inaba and Tsubone, 2020), the existence of
nested mixed-mode oscillation (MMO) bifurcation structures, generated by a driven slow …

We analyze the dynamical mechanisms underlying the formation of arrhythmogenic early
afterdepolarizations (EADs) in two mathematical models of cardiac cellular …

Arrhythmogenic early afterdepolarizations (EADs) are investigated in a biophysically
detailed mathematical model of a rabbit ventricular myocyte, providing their location in the …

Early afterdepolarization (EAD) is known to cause lethal ventricular arrhythmias in long QT
syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human …

Early afterdepolarizations (EADs) are abnormal depolarizations during the plateau phase of
the action potential, which are known to be associated with lethal arrhythmias in the heart …

Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried
by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of …