GSK-3484862 targets DNMT1 for degradation in cells
Q Chen, B Liu, Y Zeng, JW Hwang, N Dai… - Nar …, 2023 - academic.oup.com
Maintenance of genomic methylation patterns at DNA replication forks by DNMT1 is the key
to faithful mitotic inheritance. DNMT1 is often overexpressed in cancer cells and the DNA …
to faithful mitotic inheritance. DNMT1 is often overexpressed in cancer cells and the DNA …
[HTML][HTML] Cap-specific terminal N6-methyladeonsine methylation of RNA mediated by PCIF1 and possible therapeutic implications
H Zeng, Y Wu, X Long - Genes & Diseases, 2025 - Elsevier
Posttranscriptional RNA modification is an important mode of epigenetic regulation in
various biological and pathological contexts. N6, 2′-O-dimethyladenosine (m6Am) is one …
various biological and pathological contexts. N6, 2′-O-dimethyladenosine (m6Am) is one …
Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga
Much is known about the generation, removal, and roles of 5-methylcytosine (5mC) in
eukaryote DNA, and there is a growing body of evidence regarding N6-methyladenine, but …
eukaryote DNA, and there is a growing body of evidence regarding N6-methyladenine, but …
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase
S-Adenosyl-l-methionine (SAM) analogs are adaptable tools for studying and therapeutically
inhibiting SAM-dependent methyltransferases (MTases). Some MTases play significant roles …
inhibiting SAM-dependent methyltransferases (MTases). Some MTases play significant roles …
[HTML][HTML] Cap-Specific m6Am Methyltransferase PCIF1/CAPAM Regulates mRNA Stability of RAB23 and CNOT6 through the m6A Methyltransferase Activity
A Sugita, R Kano, H Ishiguro, N Yanagisawa… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Chemical modifications of cellular RNAs play key roles in gene expression and host
defense. The cap-adjacent N6, 2′-O-dimethyladenosine (m6Am) is a prevalent …
defense. The cap-adjacent N6, 2′-O-dimethyladenosine (m6Am) is a prevalent …
[HTML][HTML] PCIF1 is partly cytoplasmic, dynamically localizes to stress granules and binds mRNA coding regions upon oxidative stress
Abstract PCIF1 (Phosphorylated CTD-Interacting Factor 1) is the mRNA (2'-O-
methyladenosine-N (6)-)-methyltransferase that catalyzes the formation of cap-adjacent N 6 …
methyladenosine-N (6)-)-methyltransferase that catalyzes the formation of cap-adjacent N 6 …
Optimizing purification and activity assays of N-terminal methyltransferase complexes
HV Parker, JG Tooley, CES Tooley - Methods in enzymology, 2023 - Elsevier
In vitro methyltransferase assays have traditionally been carried out with tritiated S-adenosyl-
methionine (SAM) as the methyl donor, as site-specific methylation antibodies are not …
methionine (SAM) as the methyl donor, as site-specific methylation antibodies are not …
Intrafamily Heterooligomerization of the N-Terminal Methyltransferase METTl11A
HV Hobble - 2024 - search.proquest.com
N-terminal protein methylation is a post-translational modification (PTM) that influences a
variety of biological processes by regulating protein stability, protein-DNA interactions, and …
variety of biological processes by regulating protein stability, protein-DNA interactions, and …