[HTML][HTML] Probabilistic risk assessment–the keystone for the future of toxicology

A Maertens, E Golden, TH Luechtefeld, S Hoffmann… - Altex, 2022 - ncbi.nlm.nih.gov
Safety sciences must cope with uncertainty of models and results as well as information
gaps. Acknowledging this uncertainty necessitates embracing probabilities and accepting …

[HTML][HTML] The effect of exposure to radiofrequency fields on cancer risk in the general and working population: A systematic review of human observational studies–Part …

K Karipidis, D Baaken, T Loney, M Blettner… - Environment …, 2024 - Elsevier
Background The objective of this review was to assess the quality and strength of the
evidence provided by human observational studies for a causal association between …

[PDF][PDF] Strategic risk management in financial institutions: Ensuring robust regulatory compliance

IA Adeniran, AO Abhulimen… - Finance & Accounting …, 2024 - researchgate.net
Adeniran, Abhulimen, Obiki-Osafiele, Osundare, Agu, & Efunniyi, P. No. 1582-1596 Page
1583 compliance efforts with business strategy, ensuring that institutions are not only …

A call for a Human Exposome Project

T Hartung - ALTEX-Alternatives to animal experimentation, 2023 - altex.org
Four decades of the Human Genome Project and its consequences have shown how the
entrepreneurial state, through significant investment into science, can drive scientific …

The validation of regulatory test methods–Conceptual, ethical, and philosophical foundations

T Hartung - ALTEX-Alternatives to animal experimentation, 2024 - altex.org
Validation establishes the reproducibility and relevance of regulatory test methods,
particularly for new approach methods (NAMs) as alternatives to animal testing. While …

Principles of risk decision-making

D Krewski, P Saunders-Hastings, P Larkin… - Journal of Toxicology …, 2022 - Taylor & Francis
Risk management decisions in public health require consideration of a number of complex,
often conflicting factors. The aim of this review was to propose a set of 10 fundamental …

The implementation moonshot project for alternative chemical testing (IMPACT) toward a human exposome project

F Sillé, F Busquet, S Fitzpatrick, K Herrmann… - 2024 - kops.uni-konstanz.de
Zusammenfassung The Human Exposome Project aims to revolutionize our understanding
of how environmental exposures affect human health by systematically cataloging and …

Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic …

I Rusyn, FA Wright - Toxicological Sciences, 2024 - academic.oup.com
Systematic review and evaluation of mechanistic evidence using the Key Characteristics
approach was proposed by the International Agency for Research on Cancer (IARC) in 2012 …

Pollutants to Pathogens: The Role of Heavy Metals in Modulating TGF-β Signaling and Lung Cancer Risk

AA Bhat, E Moglad, P Bansal, H Kaur, M Deorari… - … -Research and Practice, 2024 - Elsevier
Lung cancer is a malignant tumor that develops in the lungs due to the uncontrolled growth
of aberrant cells. Heavy metals, such as arsenic, cadmium, mercury, and lead, are metallic …

Visualization strategies to aid interpretation of high‐dimensional genotoxicity data

SD Dertinger, E Briggs, Y Hussien… - Environmental and …, 2024 - Wiley Online Library
This article describes a range of high‐dimensional data visualization strategies that we have
explored for their ability to complement machine learning algorithm predictions derived from …