Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …
[HTML][HTML] Blood-brain barrier: from physiology to disease and back
MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …
pathogens from entering the brain. At the same time, the BBB regulates transport of …
The role of brain vasculature in neurodegenerative disorders
Adequate supply of blood and structural and functional integrity of blood vessels are key to
normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain …
normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain …
The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease
C Iadecola - Neuron, 2017 - cell.com
The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …
Review Group meeting of the National Institute of Neurological Disorders and Stroke …
Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …
brain has evolved a unique mechanism for CBF control known as neurovascular coupling …
Neuronal regulation of the blood–brain barrier and neurovascular coupling
L Kaplan, BW Chow, C Gu - Nature Reviews Neuroscience, 2020 - nature.com
To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …
Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling
D Zhang, J Ruan, S Peng, J Li, X Hu, Y Zhang… - Nature …, 2024 - nature.com
Neurovascular coupling (NVC) is important for brain function and its dysfunction underlies
many neuropathologies. Although cell-type specificity has been implicated in NVC, how …
many neuropathologies. Although cell-type specificity has been implicated in NVC, how …
Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow
Blood flow into the brain is dynamically regulated to satisfy the changing metabolic
requirements of neurons, but how this is accomplished has remained unclear. Here we …
requirements of neurons, but how this is accomplished has remained unclear. Here we …
Ultra-slow oscillations in fMRI and resting-state connectivity: neuronal and vascular contributions and technical confounds
Summary Ultra-slow,∼ 0.1-Hz variations in the oxygenation level of brain blood are widely
used as an fMRI-based surrogate of" resting-state" neuronal activity. The temporal …
used as an fMRI-based surrogate of" resting-state" neuronal activity. The temporal …
Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons
Brain hemodynamics serve as a proxy for neural activity in a range of noninvasive
neuroimaging techniques including functional magnetic resonance imaging (fMRI). In …
neuroimaging techniques including functional magnetic resonance imaging (fMRI). In …