The ocular tissue microenvironment is immune-privileged and uses multiple
immunosuppressive mechanisms to prevent the induction of inflammation. The retinal …

The retinal pigment epithelium (RPE) is a specialized epithelium at the back of the eye that
carries out a variety of functions essential for visual health. Recent studies have advanced …

Abstract Mutations in the Prominin‐1 (Prom1) gene disrupt photoreceptor disk
morphogenesis, leading to macular dystrophies. We have shown that human retinal pigment …

Disheveled-associated activator of morphogenesis 2 (DAAM2) regulates actin
polymerization and cell motility. In this study, we investigated the role of DAAM2 in the …

Background Transplantation of human pluripotent stem cell-derived retinal pigment
epithelium (RPE) is an urgently needed treatment for the cure of degenerative diseases of …

Visual decline in the elderly is often attributed to retinal aging, which predisposes the tissue
to pathologies such as age-related macular degeneration. Currently, effective oral …

The early and intermediate age-related macular degeneration (AMD) is characterized by the
presence of drusen and pigmentary abnormalities in the retinal pigment epithelial (RPE) …