Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

The use of antibiotics is threatened by the emergence and spread of multidrug-resistant
strains of bacteria. Thus, there is a need to develop antibiotics that address new targets. In …

Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …

The growing threat of antibiotic resistance necessitates the discovery of antibiotics that are
active against resistant pathogens. Calcium-dependent antibiotics are a small family of …

Multidrug-resistant bacteria pose a serious global health threat as antibiotics are
increasingly losing their clinical efficacy. A molecular level understanding of the mechanism …

With increasing rates of resistance toward commonly used antibiotics, especially among
Gram-negative bacteria, there is renewed interested in polymyxins. Polymyxins are …

To push back the growing tide of antibacterial resistance the discovery and development of
new antibiotics is a must. In recent years the calcium-dependent lipopeptide antibiotics …

Since Fleming's discovery of penicillin nearly a century ago, a bounty of natural product
antibiotics have been discovered, many of which continue to be of clinical importance today …

Nonribosomal lipopeptides (NRLPs) are complex natural products of bacterial origin that not
only fulfill important ecological functions but also serve as lead structures for the …