SOLVENT SIGNAL SUPPRESSION IN NMR Page 1 Pmgress ia NMR Spectroscopy, Vol. 23.
pp. 135-209, 1991. 00794565/91 SO.00 +.M Printed in Great Britain. All tights reserved 0 1991 …

It has been difficult to establish a strong correlation between total brain T2-weighted lesion
volume on MRI and clinical disability in multiple sclerosis, in part because of the lack of …

The current study was designed to determine the relative distribution of decreases of N-
acetylasparate (NAA), a marker of axonal damage, between lesions and normal-appearing …

Abstract N‐Acetylaspartate (NAA), which constitutes the major proportion of the dominant
resonance in proton MR spectra of brain, is localized in mature brain exclusively in neurons …

Two single‐shot localization techniques, STEAM and PRESS, are analyzed with regard to
specifications for in vivo localized proton NMR. In particular, attention is paid to optimum …

We report the chemical pathological changes on magnetic resonance spectroscopic images
of 4 patients, each of whom had a single large demyelinating plaque. The patients were …

Background Fatigue is a common and distressing symptom for patients with multiple
sclerosis (MS). There is growing evidence that fatigue in MS has a central nervous system …

An ultrashort-echo-time stimulated echo-acquisition mode (STEAM) pulse sequence with
interleaved outer volume suppression and VAPOR (variable power and optimized relaxation …

Experimental work in animal models of generalized epilepsy and clinical data in humans
with idiopathic generalized epilepsy (IGE) indicate that the thalamo‐cortical circuitry is …

Patients with multiple sclerosis (MS) can benefit from treatment with interferon β–1b.
However, the mechanisms of action of this drug are incompletely understood and effects of …