The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

HH Han, HM Wang, P Jangili, M Li, L Wu… - Chemical Society …, 2023 - pubs.rsc.org
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …

Recent progress in metal-organic cages for biomedical application: Highlighted research during 2018–2023

YP Wang, Y Zhang, XH Duan, JJ Mao, M Pan… - Coordination Chemistry …, 2024 - Elsevier
Metal-organic cages (MOCs) are a class of widely used nanosize supramolecular
architectures with specific geometric shapes and confined cavities, constructed from the …

Diketopyrrolopyrrole-based fluorescent probe for visualizing over-expressed carboxylesterase in fever via ratiometric imaging

B Zhang, S Qin, N Wang, X Lu, J Jiao, J Zhang, W Zhao - Talanta, 2024 - Elsevier
Fever is the result of inflammation and the innate self-defense response of organisms, can
cause abnormal changes in the activity of many enzymes in organisms, including the …

An “all in one” strategy to boost antibacterial phototherapy via porphyrin and boron dipyrromethenes based covalent organic framework

SS Zhao, XP Guo, XH Pan, YB Huang, R Cao - Chemical Engineering …, 2023 - Elsevier
Bacterial drug resistant is considered as a major threat to human health. Antibacterial
phototherapy (PT) including photodynamic and photothermal therapy has attracted …

A highly sensitive and selective near-infrared fluorescent probe for imaging peroxynitrite in living cells and drug-induced liver injury mice

X Chai, B Li, C Chen, W Zhang, L Sun… - Analytical …, 2023 - ACS Publications
Drug-induced liver injury (DILI) is a major clinical issue associated with the majority of
commercial drugs. During DILI, the peroxynitrite (ONOO–) level is upregulated in the liver …

Rational design of novel lipophilic aggregation-induced emission probes for revealing the dynamics of lipid droplets during lipophagy and ferroptosis

R Chen, Z Li, C Peng, L Wen, L Xiao, Y Li - Analytical Chemistry, 2022 - ACS Publications
Lipid droplets (LDs), as crucial organelles, play a significant role in some physiological
processes. Monitoring the concentration of LDs and dynamic behaviors between LDs and …

Phenotyping of Methicillin-Resistant Staphylococcus aureus Using a Ratiometric Sensor Array

XL Hu, HQ Gan, ZY Qin, Q Liu, M Li… - Journal of the …, 2023 - ACS Publications
Chemical tools capable of classifying multidrug-resistant bacteria (superbugs) can facilitate
early-stage disease diagnosis and help guide precision therapy. Here, we report a sensor …

Kidney-Targeted Near-Infrared Fluorescence Probe Reveals That SO2 Is a Biomarker for Cisplatin-Induced Acute Kidney Injury

S Jiang, J Hong, S Gong, Q Li, G Feng - Analytical Chemistry, 2023 - ACS Publications
With the widespread use of drugs, drug-induced acute kidney injury (AKI) has become an
increasingly serious health concern worldwide. Currently, early diagnosis of drug-induced …

Bifunctional Single-Molecular Fluorescent Probe: Visual Detection of Mitochondrial SO2 and Membrane Potential

W Ai, Y Bu, H Huang, J Wang, M Ren, Y Deng… - Analytical …, 2023 - ACS Publications
Mitochondrial membrane potential (MMP) and sulfur dioxide (SO2) significantly affect the
mitochondrial state. In this work, TC-2 and TC-8 were constructed through side-chain …

Probing fluctuations in sulfur dioxide and viscosity levels during mitochondrial dysfunction using a dual-response fluorescent probe with good water solubility

H Zhang, W Cheng, S Zeng, B Wang, X Song - Analyst, 2023 - pubs.rsc.org
Mitochondrial dysfunction is associated with increased viscosity and reactive oxygen
species (ROS) levels. As an effective antioxidant, sulfur dioxide (SO2) can actively scavenge …