Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …

Purpose: Most patients with pancreatic ductal adenocarcinoma (PDAC) have vascular
invasion and metastasis, leading to low surgical resection rate and dismal prognosis. Tumor …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

Background MicroRNAs are short regulatory RNAs that negatively modulate protein
expression at a post-transcriptional and/or translational level and are deeply involved in the …

Skeletal development (bone modeling) and its maintenance in post-natal life in response to
local and systemic stimuli (bone remodeling) require coordinated activity among osteoblasts …

Across the world, oral cancer is a prevalent tumor. Over the years, both its mortality and
incidence have grown. Oral cancer metastasis is a complex process involving cell invasion …

Direct communication between cells, mediated by gap junctions, is nowadays considered as
an indispensable mechanism in the maintenance of cellular homeostasis. In fact, gap …

Connexins, a family of transmembrane proteins, are components of both gap junction
channels and hemichannels, which mediate the exchange of ions and small molecules …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …