Macrophages have important roles in immune surveillance and in the maintenance of
kidney homeostasis; their response to renal injury varies enormously depending on the …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The
primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its …

Background A challenge for single-cell genomic studies in kidney and other solid tissues is
generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate …

The regulation and importance of monocyte chemoattractant pr... : Current Opinion in
Hematology The regulation and importance of monocyte chemoattractant protein-1 : Current …

Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health
expenditures worldwide. Obesity is a significant risk factor for CKD development, partially …

Objective This study aimed to evaluate the safety of avacopan, an orally administered C5a
receptor inhibitor, for the treatment of antineutrophil cytoplasmic antibody (ANCA) …

Inflammation is a key characteristic of kidney disease, but this immune response is two-
faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight …

Acute kidney injury (AKI) is associated with significant morbidity and its chronic inflammation
contributes to subsequent chronic kidney disease (CKD) development. Yes-associated …

Background: Ferroptosis, an iron-dependent form of regulated necrosis mediated by lipid
peroxidation, predominantly polyunsaturated fatty acids, is involved in postischemic and …

The dietary supplement, trans-resveratrol and hesperetin combination (tRES-HESP),
induces expression of glyoxalase 1, countering the accumulation of reactive dicarbonyl …