Efficacy and Safety of Five Broad-Spectrum Antiseizure Medications for Adjunctive Treatment of Refractory Epilepsy: A Systematic Review and Network Meta-Analysis

H Wang, H Wang, Y Liu, J Zhao, X Niu, L Zhu, X Ma… - CNS drugs, 2023 - Springer
Background Overall, up to one-third of epilepsy patients have drug-resistant epilepsy.
However, there was previously no meta-analysis to support the guidelines for broad …

Quantifying and controlling the impact of regression to the mean on randomized controlled trials in epilepsy

DM Goldenholz, EB Goldenholz, TJ Kaptchuk - Epilepsia, 2023 - Wiley Online Library
Abstract Objective Randomized controlled trials (RCTs) in epilepsy for drug treatments are
plagued by high costs. One potential remedy is to reduce placebo response via better …

Anti-seizures therapeutics in patients with epilepsy: an approach to levetiracetam–review

B Rusinowska - Journal of Education, Health and Sport, 2022 - apcz.umk.pl
Epilepsy is a chronic condition that consists of a transient disorder of brain function
manifested by recurrent and unprovoked seizures affecting approximately 50 million people …

[HTML][HTML] The effect of levetiracetam on depression and anti-oxidant activity in patients with epilepsy

J Mehvari-Habibabadi, M Zare… - Current Journal of …, 2022 - ncbi.nlm.nih.gov
Background: Levetiracetam (LEV) is approved for treating epilepsy. The current evidence
shows that LEV can cause behavioral problems such as depression. It is well-known that …

左乙拉西坦治疗药物监测的研究进展

高畅, 倪斌, 陈芳辉, 郭春钰, 魏桂林 - 中国药房, 2024 - journal.china-pharmacy.com
左乙拉西坦(LEV) 是第二代广谱抗癫痫药物, 具有起效快, 半衰期短, 疗效确切, 耐受性好,
药物相互作用少等优点. 为提高LEV 的临床效果, 减少不良反应的发生, 应对儿童, 妊娠期妇女 …

The optimized biocatalytic synthesis of (S)‐methyl 2‐chlorobutanoate by Acinetobacter sp. lipase

Y Lu, R Zhan, B Song, Y Zhou, L Zhu, H Chen… - Chirality, 2022 - Wiley Online Library
Epilepsy is a chronic disease caused by sudden abnormal discharge of brain neurons,
leading to transient brain dysfunction. Levetiracetam, developed by the UCB company in …

Comparative effect of levetiracetam and carbamazepine versus levetiracetam and sodium valproate on seizure frequency in patients with epilepsy

S Nazarbaghi, H Hosseinpour… - Journal of Physical …, 2022 - scientificarchives.com
Introduction: One of the drugs that are added to common treatments in drug-resistant
epilepsy is levetiracetam. Objectives: In this study, the effect of levetiracetam and …

[PDF][PDF] Practical drug treatment recommendations on the drug refractory epilepsy patients: 2021 Clinical Guideline Subcommittee for Epilepsy in the Korean …

DJ Shin, YM Shon, KY Jung, YS Koo, D Kim… - Journal of the Korean …, 2021 - jkna.org
One third of the overall epilepsy population are estimated to be a drug refractory epilepsy
(DRE), defined as the patients who failed to control seizure reduction, even tried two or more …

Research progress in therapy drug monitoring of levetiracetam

C Gao, B NI, F Chen, C Guo, G Wei - China Pharmacy, 2024 - pesquisa.bvsalud.org
Levetiracetam (LEV) is the second generation of broad-spectrum anti-epileptic drug. LEV
has the advantages of rapid absorption, short half-life, precise efficacy, good tolerance and …

[PDF][PDF] A cross-sectional comparative study to evaluate the efficacy and safety of levetiracetam with other antiepileptics among epileptic patients at a tertiary care …

PS Anupama, C Biju, M Hareesh, LJ Thomas, CC Nair… - 2025 - journalwjbphs.com
Background: Epilepsy is a neurological disorder characterized by recurrent seizures, and
about one-third of patients do not respond to a single antiepileptic drug (AED) …