Galectin-3 is the only chimeric representative of the galectin family. Although galectin-3 has
ubiquitous regulatory and physiological effects, there is a great number of pathological …

Glycans have been shown to function as versatile molecular signals in cells. This prompted
us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by …

FGF/FGFR signaling is critical for the development and homeostasis of the human body and
imbalanced FGF/FGFR contributes to the progression of severe diseases, including cancers …

Besides being recognized by membrane receptor TLR4, lipopolysaccharide (LPS) can also
be internalized into the cytosol and activate Caspase-4/11 pyroptotic pathways to further …

The treatment of chronic inflammation with systemically administered anti-inflammatory
treatments is associated with moderate-to-severe side effects, and the efficacy of locally …

The design of completely synthetic proteins from first principles—de novo protein design—is
challenging. This is because, despite recent advances in computational protein–structure …

Bone-resorbing osteoclasts mobilize proteolytic enzymes belonging to the matrix
metalloproteinase (MMP) family to directly degrade type I collagen, the dominant …

Carbohydrates are more than an energy-storage. They are ubiquitously found on cells and
most proteins, where they encode biological information. Lectins bind these carbohydrates …

Galectin-8 is a small soluble lectin with two carbohydrate recognition domains (CRDs). N-
and C-terminal CRDs of Gal-8 differ in their specificity for glycan ligands. Here, we wanted to …

Polypeptide fusion tags that can direct the assembly of folded proteins into supramolecular
networks are attractive for creating functional biomaterials. A practical challenge is …