Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
S Dupont - Experimental cell research, 2016 - Elsevier
Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …
proliferation, opposes cell death and regulates differentiation. Through integrins, cells …
The central role of muscle stem cells in regenerative failure with aging
HM Blau, BD Cosgrove, ATV Ho - Nature medicine, 2015 - nature.com
Skeletal muscle mass, function, and repair capacity all progressively decline with aging,
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated …
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated …
The mechanobiology of aging
JM Phillip, I Aifuwa, J Walston… - Annual review of …, 2015 - annualreviews.org
Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …
over an extended period of time. Aging is accompanied by major biochemical and …
[HTML][HTML] Aging-associated alterations in mammary epithelia and stroma revealed by single-cell RNA sequencing
Aging is closely associated with increased susceptibility to breast cancer, yet there have
been limited systematic studies of aging-induced alterations in the mammary gland. Here …
been limited systematic studies of aging-induced alterations in the mammary gland. Here …
Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells
A primary function of DNA methylation in mammalian genomes is to repress transposable
elements (TEs). The widespread methylation loss that is commonly observed in cancer cells …
elements (TEs). The widespread methylation loss that is commonly observed in cancer cells …
Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors
CH Lin, FA Pelissier, H Zhang, J Lakins… - Molecular biology of …, 2015 - Am Soc Cell Biol
Stiffness is a biophysical property of the extracellular matrix that modulates cellular
functions, including proliferation, invasion, and differentiation, and it also may affect …
functions, including proliferation, invasion, and differentiation, and it also may affect …
Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons
MM Adil, T Vazin, B Ananthanarayanan… - Biomaterials, 2017 - Elsevier
Cell replacement therapies have broad biomedical potential; however, low cell survival and
poor functional integration post-transplantation are major hurdles that hamper clinical …
poor functional integration post-transplantation are major hurdles that hamper clinical …
Tissue stiffness and hypoxia modulate the integrin-linked kinase ILK to control breast cancer stem-like cells
Breast tumors are stiffer and more hypoxic than nonmalignant breast tissue. Here we report
that stiff and hypoxic microenvironments promote the development of breast cancer stem …
that stiff and hypoxic microenvironments promote the development of breast cancer stem …
Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations
During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by
expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of …
expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of …
Nuclear lamins in cancer
Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying
in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies …
in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies …