The perineuronal net (PNN) is a highly latticed extracellular matrix in the central nervous
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan …

It is generally believed that immune activation can elicit pain through production of
inflammatory mediators that can activate nociceptive sensory neurons. Emerging evidence …

Pain and itch are two closely related but essentially distinct sensations that elicit different
behavioral responses. However, it remains mysterious how pain and itch information is …

The anterolateral system (ALS) is a major ascending pathway from the spinal cord that
projects to multiple brain areas and underlies the perception of pain, itch, and skin …

Induced pluripotent stem cells (iPSCs) can be personalized and differentiated into neural
stem cells (NSCs), thereby effectively providing a source of transplanted cells for spinal cord …

Postoperative pain management would benefit significantly from an anesthetic that could
take effect in an on-demand manner. An ultrasound would be an appropriate tool for such …

Despite the recognized importance of the spinal cord in sensory processing, motor
behaviors, and neural diseases, the underlying organization of neuronal clusters and their …

Obesity affects more than a third adult population in the United States; the prevalence is
even higher in patients with major depression disorders. GWAS studies identify the receptor …

Neuropeptide Y targets the Y1 receptor (Y1) in the spinal dorsal horn (DH) to produce
endogenous and exogenous analgesia. DH interneurons that express Y1 (Y1-INs; encoded …

Animal models of peripheral nerve injury (PNI) serve as the fundamental basis for the
investigations of nerve injury, regeneration, and neuropathic pain. The injury properties of …