Liver failure affects brain function, leading to neurological and psychiatric alterations; such
alterations are referred to as hepatic encephalopathy (HE). Early diagnosis of minimal HE …

Recent work on glial cell physiology has revealed that glial cells, and astrocytes in
particular, are much more actively involved in brain information processing than previously …

Hyperammonemia resulting from inherited urea cycle enzyme deficiencies or liver failure
results in severe central nervous system dysfunction including brain edema, convulsions …

Hepatic encephalopathy (HE) is a neurological disorder that occurs in patients with liver
insufficiency. However, its pathogenesis has not been fully elucidated. Pharmacotherapy is …

Glutamate fulfils many vital functions both at a peripheral level and in the central nervous
system (CNS). However, hyperammonemia and hepatic failure induce alterations in …

Patients with hepatic encephalopathy (HE) may present different neurological alterations
including impaired cognitive function and altered motor activity and coordination. HE may …

Brain dysfunction is a severe complication of sepsis with an incidence ranging from 9% to
71% that is associated with increased morbidity and mortality. Its diagnosis relies mainly on …

Sirtuins are highly conserved NAD+ dependent class III histone deacetylases and catalyze
deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require …

Long chain acyl-CoA dehydrogenase (LCAD) has recently been shown to be the
mitochondrial enzyme responsible for the β-oxidation of branched chain and unsaturated …

Attention deficit is an early event in the cognitive impairment of patients with minimal hepatic
encephalopathy (MHE). The underlying mechanisms remain unclear. Mismatch negativity …