Long non-coding RNAs (lncRNAs) are diverse transcription products emanating from
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …

DNA methylation is one of the most important epigenetic mechanisms to regulate gene
expression, which is highly dynamic during development and specifically maintained in …

Our genomes contain the blueprint of what makes us human and many indications as to why
we develop disease. Until the last 10 years, most studies had focussed on protein‐coding …

Long non-coding RNAs (lncRNAs) can act as scaffolds that promote the interaction of
proteins, RNA, and DNA. There is increasing evidence of sequence-specific interactions of …

Transposon (de) repression and heterochromatin reorganization are dynamically regulated
during cell fate determination and are hallmarks of cellular senescence. However, whether …

The epigenetic landscape has an important role in cellular homeostasis and its deregulation
leads to cancer. Noncoding (nc) RNA networks function as major regulators of cellular …

DNA methylation is one of the most important epigenetic mechanisms that governing
regulation of gene expression, aberrant DNA methylation patterns are strongly associated …

Pluripotent stem cells have broad applications in regenerative medicine and offer ideal
models for understanding the biological process of embryonic development and specific …

The blueprints of developing organs are preset at the early stages of embryogenesis.
Transcriptional and epigenetic mechanisms are proposed to preset developmental …

Atherosclerosis is a chronic inflammatory disease that is driven, in part, by activation of
vascular endothelial cells (ECs). In response to inflammatory stimuli, the nuclear factor …