Recent advance in oxazole-based medicinal chemistry
HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
Anti-cancer activity of derivatives of 1, 3, 4-oxadiazole
Compounds containing 1, 3, 4-oxadiazole ring in their structure are characterised by
multidirectional biological activity. Their anti-proliferative effects associated with various …
multidirectional biological activity. Their anti-proliferative effects associated with various …
New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFRWT and EGFRT790M Inhibitors: Microwave-Assisted Synthesis …
A new series of benzimidazole, 1, 2, 4-triazole, and 1, 3, 5-triazine derivatives were
designed and synthesized using a microwave irradiation synthetic approach utilizing 2 …
designed and synthesized using a microwave irradiation synthetic approach utilizing 2 …
Oxadiazole: A highly versatile scaffold in drug discovery
N Desai, J Monapara, A Jethawa… - Archiv der …, 2022 - Wiley Online Library
As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …
problem associated with the confluence of many commercially available drugs with different …
Naproxen based 1, 3, 4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies
MM Alam, S Nazreen, ASA Almalki, AA Elhenawy… - Pharmaceuticals, 2021 - mdpi.com
A library of novel naproxen based 1, 3, 4-oxadiazole derivatives (8–16 and 19–26) has been
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer
A series of novel amidino 2-substituted benzimidazoles linked to 1, 4-disubstituted 1, 2, 3-
triazoles were synthesized by implementation of microwave and ultrasound irradiation in …
triazoles were synthesized by implementation of microwave and ultrasound irradiation in …
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors
AM Srour, NS Ahmed, SS Abd El-Karim… - Bioorganic & Medicinal …, 2020 - Elsevier
Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
Synthesis and anticancer evaluation of new 1, 3, 4-oxadiazole derivatives
In order to develop novel chemotherapeutic agents with potent anticancer activities, a series
of new 2, 5-diaryl/heteroaryl-1, 3, 4-oxadiazoles were designed and synthesized. The …
of new 2, 5-diaryl/heteroaryl-1, 3, 4-oxadiazoles were designed and synthesized. The …
Synthesis of stable benzimidazole derivatives bearing pyrazole as anticancer and EGFR receptor inhibitors
A new series of benzimidazole linked pyrazole derivatives were synthesized by
cyclocondensation reaction through one-pot multicomponent reaction in absolute ethanol …
cyclocondensation reaction through one-pot multicomponent reaction in absolute ethanol …
Recent advancements on benzimidazole: A versatile scaffold in medicinal chemistry
ZMM Alzhrani, MM Alam… - Mini Reviews in Medicinal …, 2022 - ingentaconnect.com
Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …