A wide range of insults can trigger axon degeneration, and axons respond with diverse
morphology, topology and speed. However, recent genetic, immunochemical, morphological …

Background Spinal cord injury (SCI) is a devastating event often resulting in permanent
neurologic deficit. Research has revealed an understanding of mechanisms that occur after …

Spinal cord injury (SCI) leads to robust Rho activation at the lesion site. Here, we
demonstrate that BA-210, a cell-permeable fusion protein derived from C3 transferase …

Myelin-associated glycoprotein (MAG) and Nogo are potent inhibitors of neurite outgrowth
from a variety of neurons, and they have been identified as possible components of the …

Introduction 3. Rho GTPase effectors 3.1. Rac/Cdc42/PAK 3.2. Rho/ROCK 3.3. Cdc42/ACK
4. Rho GTPases, neuronal growth cone dynamics, and dendritic spine morphogenesis 5 …

An increasing number of therapies for spinal cord injury (SCI) are emerging from the
laboratory and seeking translation into human clinical trials. Many of these are administered …

The GTP-binding protein RhoA regulates microfilament dynamics in many cell types and
mediates the inhibition of axonal regeneration by myelin and chondroitin sulfate …

Ibuprofen is a nonsteroidal anti-inflammatory drug widely used to relieve pain and
inflammation in many disorders via inhibition of cyclooxygenases. Recently, we have …

Limited axonal plasticity within the central nervous system (CNS) is a major restriction for
functional recovery after CNS injury. The small GTPase RhoA is a key molecule of the …

The regeneration of adult peripheral neurons after transection is slow, incomplete and
encumbered by severe barriers to proper regrowth. The role of RHOA GTPase has not been …