BACKGROUND The central nervous system (CNS) can be a sanctuary site for cancer cells,
because the blood‐brain barrier impedes penetration of most chemotherapeutic agents. The …

Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common
in paediatric oncology for diagnosis, risk stratification and molecularly targeted therapeutics …

Disseminating disease is a predictive and prognostic indicator of poor outcome in children
with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment …

Purpose: GD2 is abundantly expressed in neuroblastoma (NB). GD2 synthesis is dependent
on key enzyme β 1, 4-N-acetylgalactosaminyltransferase (GD2 synthase). We explore the …

While cyto-and histological screening of bone marrow samples are still accepted as the gold
standard for initial staging of neuroblastoma patients, these applications are insufficient …

Purpose: To improve the detection of disseminated tumor cells in bone marrow (BM) and
peripheral blood samples of solid tumor patients, a novel computer-assisted scanning …

The sensitive detection of bone marrow involvement is crucial for tumor staging at diagnosis
and for monitoring of the therapeutic response in the patient's follow-up. In neuroblastoma …

BACKGROUND Neuroblastomas (NBs) almost ubiquitously express the ganglioside GD2.
GD2 synthesis is dependent on the key enzyme GD2 synthase. Thus, GD2 synthase …

Neuroblastoma (NB) is a pediatric cancer of highly variable clinical outcome. Much effort is
devoted to detection of minimal residual (MRD) disease through RT-PCR or immunology of …

Several transcripts have been claimed to be clinically valuable for detecting minimal disease
in neuroblastoma, but they have not been prospectively compared in a standardized …