The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The with no lysine (K)(WNK) kinases are an evolutionarily ancient group of kinases with
atypical placement of the catalytic lysine and diverse physiological roles. Recent studies …

With-no-lysine (WNK) kinases regulate renal sodium-chloride cotransporter (NCC) to
maintain body sodium and potassium homeostasis. Gain-of-function mutations of WNK1 and …

The kidney plays an essential role in maintaining homeostasis of ion concentrations in the
blood. Because the concentration gradient of potassium across the cell membrane is a key …

With No Lysine (K) WNK kinases regulate electro-neutral cotransporters that are controlled
by osmotic stress and chloride. We showed previously that autophosphorylation of WNK1 is …

The lymphatic system is an integral part of the circulatory system and plays an important role
in the fluid homeostasis of the human body. Accumulating evidence has recently suggested …

Genome-wide analysis of renal sodium-transporting system has identified specific variations
of Mendelian hypertensive disorders, including HSD11B2 gene variants in apparent …

Metastasis is the major cause of mortality in cancer patients. Analyses of mouse models and
patient data have implicated the protein kinase WNK1 as one of a handful of genes uniquely …

WNK (With no Lysine [K]) kinases have critical roles in the maintenance of ion homeostasis
and the regulation of cell volume. Their overactivation leads to pseudohypoaldosteronism …

Diuretics are commonly prescribed for treatment in patients with hypertension, edema, or
heart failure. Studies on hypertensive and salt‐losing disorders and on urea transporters …