The ability to split one cell into two is fundamental to all life, and many bacteria can
accomplish this feat several times per hour with high accuracy. Most bacteria call on an …

Widespread antimicrobial resistance among bacterial pathogens is a serious threat to public
health. Thus, identification of new targets and development of new antibacterial agents are …

The global spread of bacterial antimicrobial resistance is associated to millions of deaths
from bacterial infections per year, many of which were previously treatable. This, combined …

Abstract New leukotriene B4 (LTB4) antagonists have been synthesized that can be
considered as potential anti-inflammatory drugs. Structures containing the dioxygenated …

Cytokinesis is a fundamental process for bacterial survival and proliferation, involving the
formation of a ring by filaments of the GTPase FtsZ, spatio-temporally regulated through the …

The conserved process of cell division in bacteria has been a long-standing target for
antimicrobials, although there are few examples of potent broad-spectrum compounds that …

FtsZ is an essential bacterial protein abundantly studied as a novel and promising target for
antimicrobials. FtsZ is highly conserved among bacteria and mycobacteria, and it is crucial …

The widespread emergence of antimicrobial resistance (AMR) is a serious threat to global
public health and among Gram-positive cocci, Streptococcus pneumoniae constitutes a …

Background: Staphylococcus aureus is a pathogen that has become resistant to different
antibiotics, which makes it a threat to human health. Although the first penicillin-resistant …

A series of thiouracil derivatives containing coumarin were designed and synthesized with
SecA inhibitor 1 as the lead. The in vitro antibacterial activities of the newly synthesized …