Chemical probes and methods for the study of protein arginine methylation

T Brown, T Nguyen, B Zhou, YG Zheng - RSC Chemical Biology, 2023 - pubs.rsc.org
Protein arginine methylation is a widespread post-translational modification (PTM) in
eukaryotic cells. This chemical modification in proteins functionally modulates diverse …

[HTML][HTML] Investigation of phenyl azide photochemistry by conventional and time-resolved spectroscopy. Elucidation of intermediates and reaction mechanisms

E Leyva, MS Platz, E Moctezuma - Journal of Photochemistry and …, 2022 - Elsevier
Early studies of the photochemistry of parent phenyl azide concerned the products obtained
under specific experimental conditions. Depending on the products, various mechanisms …

Quantitative structure–activity relationship machine learning models and their applications for identifying viral 3CLpro-and RdRp-targeting compounds as potential …

J Ivanov, D Polshakov, J Kato-Weinstein, Q Zhou… - ACS …, 2020 - ACS Publications
In response to the ongoing COVID-19 pandemic, there is a worldwide effort being made to
identify potential anti-SARS-CoV-2 therapeutics. Here, we contribute to these efforts by …

The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain …

IW Kim, XH Peng, ZE Sauna, PC FitzGerald, D Xia… - Biochemistry, 2006 - ACS Publications
Each nucleotide-binding domain (NBD) of mammalian P-glycoproteins (Pgps) and human
ATP-binding cassette (ABC) B subfamily members contains a tyrosine residue∼ 25 residues …

Oxidation of adenosine and inosine: the chemistry of 8-oxo-7, 8-dihydropurines, purine iminoquinones, and purine quinones as observed by ultrafast spectroscopy

DI Nilov, DY Komarov, MS Panov… - Journal of the …, 2013 - ACS Publications
Oxidative damage to purine nucleic acid bases proceeds through quinoidal intermediates
derived from their corresponding 8-oxo-7, 8-dihydropurine bases. Oxidation studies of 8-oxo …

Reactions in the conjugated 'ene–ene–yne'manifold: five-membered ring fragmentation and ring formation via coarctate/pseudocoarctate mechanisms

LD Shirtcliff, SP McClintock, MM Haley - Chemical Society Reviews, 2008 - pubs.rsc.org
The fragmentation of a 5-membered heteroaromatic ring to afford a conjugated ene–ene–
yne skeleton, and the corresponding reverse process, cyclization of the hetero-ene–ene …

The ability of triplet nitrenes to abstract hydrogen atoms

J Sankaranarayanan, S Rajam… - Journal of Physical …, 2010 - Wiley Online Library
The enthalpies for H‐atom abstraction reactions by triplet imidogen as well as ethyl,
alkoxycarbonyl, acyl, phenyl, and vinyl nitrenes were calculated using density functional …

Aryl azide photochemistry in defined protein environments

JL Morris, SC Reddington, DM Murphy, DD Jones… - Organic …, 2013 - ACS Publications
A genetically encoded precursor to an aryl nitrene, para-azidophenylalanine, was
introduced site specifically into proteins to deduce if distinct environments were capable of …

Photodissociation of aromatic azides

MF Budyka - Russian Chemical Reviews, 2008 - iopscience.iop.org
Quantitative data on the photochemical activity of aromatic azides and on the mechanism
and kinetics of azido group photodissociation are analysed and described systematically for …

Synthesis and Properties of 6-Aryl-4-azidocinnolines and 6-Aryl-4-(1,2,3-1H-triazol-1-yl)cinnolines

NA Danilkina, NS Bukhtiiarova, AI Govdi, AA Vasileva… - Molecules, 2019 - mdpi.com
An efficient approach towards the synthesis of 6-aryl-4-azidocinnolines was developed with
the aim of exploring the photophysical properties of 6-aryl-4-azidocinnolines and their click …