Nature often uses cascade reactions in a highly stereocontrolled manner for assembly
structurally diverse nitrogen-containing heterocyclic scaffolds, ie secondary metabolites …

The multicomponent reaction of aldehydes, amines, and alkynes, known as A3 coupling,
yields propargylamines, a valuable organic scaffold, and has received significant interest …

The embedding of metal nanoparticles (NPs) in metal–organic frameworks (MOFs) has
attracted a wide range of attention in the field of catalysis due to the high agglomeration …

Globally, cancer is growing more prevalent and affects the great majority of people; as a
result, new anticancer medications are presently being developed, and their safety is …

Since Strecker's discovery of multicomponent reactions (MCRs) in 1850, the strategy of
applying an MCR approach has been in use for over a century. Due to their ability to quickly …

Propargylamine is a chemical moiety whose properties have made it a widely distributed
group within the fields of medicinal chemistry and chemical biology. Its particular reactivity …

The synthesis of ester-containing heterocyclic compounds via multicomponent reaction is
one of the preferable processes in synthetic organic chemistry and medicinal chemistry …

Twenty six propargylamine mycophenolate analogues were designed and synthesized from
mycophenolic acid 1 employing a key step A 3-coupling reaction. Their cytotoxic activity was …

Alkynes have two active positions to carry out chemical reactions: CC and C–H. These two
positions are involved and activated in different reactions using different reagents. In this …

Several simple, fast and practical protocols have been developed to synthesize internal or
terminal propargylamines and chalcones via A 3-coupling reaction of aldehydes, amines …