Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage

DCW Li, S Rudloff, HT Langer, K Norman, C Herpich - Cells, 2024 - mdpi.com
Understanding the intricate mechanisms governing the cellular response to resistance
exercise is paramount for promoting healthy aging. This narrative review explored the age …

Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in lamin A/C-deficient mice

TJ Kirby, HC Zahr, EHH Fong, J Lammerding - Cell death discovery, 2024 - nature.com
Lamins A and C, encoded by the LMNA gene, are nuclear intermediate filaments that
provide structural support to the nucleus and contribute to chromatin organization and …

The proteasome regulates body weight and systemic nutrient metabolism during fasting

HT Langer, SR Taylor, M Ahmed… - American Journal …, 2023 - journals.physiology.org
The ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway are the
primary means of degradation in mammalian tissues. We sought to determine the individual …

Pathology deterioration in a pure β-zero thalassemia heterozygote after mRNA COVID-19 vaccination: A case report and literature review

AM Kyriakopoulos, S Seneff - International Journal of Vaccine Theory …, 2024 - mail.ijvtpr.com
Background: β-thalassemia heterozygotes produce sensitive levels of fetal hemoglobin and
hemoglobin A2 to remain asymptomatic for life compared to β-thalassemia intermedia and β …

Mitochondrial and proteasome dysfunction occurs in the hearts of mice treated with triazine herbicide Prometryn

RO Sule, BS Phinney, MR Salemi… - International Journal of …, 2023 - mdpi.com
Prometryn is a methylthio-s-triazine herbicide used to control the growth of annual broadleaf
and grass weeds in many cultivated plants. Significant traces of prometryn are documented …

Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling

RO Sule, C Morisseau, J Yang, BD Hammock… - Scientific Reports, 2024 - nature.com
Oxylipins are a group of bioactive fatty acid metabolites generated via enzymatic
oxygenation. They are notably involved in inflammation, pain, vascular tone, hemostasis …

P53 Activation Promotes Maturational Characteristics of Pluripotent Stem Cell‐Derived Cardiomyocytes in 3‐Dimensional Suspension Culture Via FOXO‐FOXM1 …

N Velayutham, JC Garbern, HLT Elwell… - Journal of the …, 2024 - ahajournals.org
Background Current protocols generate highly pure human induced pluripotent stem cell–
derived cardiomyocytes (hiPSC‐CMs) in vitro that recapitulate characteristics of mature in …

Role of p53 in cisplatin-induced myotube atrophy

C Matsumoto, H Sekine, N Zhang, S Mogami… - International Journal of …, 2023 - mdpi.com
Chemotherapy-induced sarcopenia is an unfavorable prognostic factor implicated in the
development of postoperative complications and reduces the quality of life of patients with …

Overexpression of miR-29ab1 Cluster Results in Excessive Muscle Growth in 1-Month-old Mice by Inhibiting Mstn

C Liu, Y Cao, L Li, Y Wang, Q Meng - DNA and Cell Biology, 2023 - liebertpub.com
Skeletal muscle mass is closely related to strength and health. Multiple genes and signaling
pathways are involved in the regulation of skeletal muscle hypertrophy. miR-29 can …

Eliminating elevated p53 signaling in Lmna-mutant mice fails to rescue skeletal muscle defects or extend survival

TJ Kirby, HC Zahr, EHH Fong, J Lammerding - bioRxiv, 2022 - biorxiv.org
Lamins A and C, encoded by the LMNA gene, are nuclear intermediate filaments that
provide structural support to the nucleus and contribute to chromatin organization and …