Introduction Toxoplasmosis constitutes a challenge for public health, animal production, and
welfare. So far, only a limited panel of drugs has been marketed for clinical applications. In …

Toxoplasmosis and neosporosis are closely related protozoan diseases that lead to
important economic impacts in farm ruminants. Toxoplasma gondii infection mainly causes …

Key features: Written by the scientist who named this parasite and was the first to set up
proper diagnostic techniques Serves as the first ever book to provide information on the …

New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by
the protozoan parasite Toxoplasma gondii. To this end, we previously developed a potent …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

We report on the in vitro effects of the bumped kinase inhibitor 1294 (BKI-1294) in cultures of
virulent Neospora caninum isolates Nc-Liverpool (Nc-Liv) and Nc-Spain7 and in two strains …

Introduction: Despite the fact that diseases caused by protozoan parasites represent serious
challenges for public health, animal production and welfare, only a limited panel of drugs …

The protozoan Neospora caninum is a primary infectious cause of abortion in cattle that
causes significant economic losses worldwide. Because effective vaccines and licensed …

Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence,
disruption of essential protein kinase function has been explored for therapy of parasitic …

Bumped kinase inhibitors (BKIs) target the apicomplexan calcium-dependent protein kinase
1 (CDPK1). BKI-1748, a 5-aminopyrazole-4-carboxamide compound when added to …