The stochasticity of transcription can be quantified by mRNA distribution $ P_m (t) $, the
probability that there are $ m $ mRNA molecules for the gene at time $ t $ in one cell …

Randomness in gene transcription can result in fluctuations (noise) of messenger RNA
(mRNA) levels, leading to phenotypic plasticity in the isogenic populations of cells. Recent …

The periodic transcription output is ubiquitously observed in an isogenic cell population. To
understand mechanisms of cyclic behavior in transcription, we extend the gene activation …

Gene transcription is a stochastic process, manifested by the heterogeneous mRNA
distribution in an isogenic cell population. Bimodal distribution has been observed in the …

Transcriptional bursting has been attributed to the random switch between the off and on
states of genes. Previous studies modeled gene activation as a process involving ordered …

Increasing experimental evidences suggest that cell phenotypic variation often depends on
the accumulation of some special proteins. Recently, a lot of studies have shown that the …

Synthesis of individual molecules in the expression of genes often occurs in bursts of
multiple copies. Gene regulatory feedback can affect the frequency with which these bursts …