Radiation-induced liver disease and modern radiotherapy

EJ Koay, D Owen, P Das - Seminars in radiation oncology, 2018 - Elsevier
Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered
to patients with primary and secondary malignancies of the liver. The current clinical practice …

Role and future of MRI in radiation oncology

IJ Das, KP McGee, N Tyagi… - The British journal of …, 2019 - academic.oup.com
Technical innovations and developments in areas such as disease localization, dose
calculation algorithms, motion management and dose delivery technologies have …

Individualized adaptive stereotactic body radiotherapy for liver tumors in patients at high risk for liver damage: a phase 2 clinical trial

M Feng, K Suresh, MJ Schipper, L Bazzi… - JAMA …, 2018 - jamanetwork.com
Importance Patients with preexisting liver dysfunction could benefit the most from
personalized therapy for liver tumors to balance maximal tumor control and minimal risk of …

Radiation-induced liver toxicity

P Munoz-Schuffenegger, S Ng, LA Dawson - Seminars in radiation …, 2017 - Elsevier
The advent of highly conformal radiation therapy (RT) has defined a new role for RT in the
treatment of both primary and metastatic liver cancer. Despite major advances in how RT is …

Modeling of normal tissue complications using imaging and biomarkers after radiation therapy for hepatocellular carcinoma

I El Naqa, A Johansson, D Owen, K Cuneo… - International Journal of …, 2018 - Elsevier
Purpose To develop normal tissue complications (NTCP) models for hepatocellular cancer
(HCC) patients who undergo liver radiation therapy (RT) and to evaluate the potential role of …

Gastrointestinal 4D MRI with respiratory motion correction

A Johansson, JM Balter, Y Cao - Medical physics, 2021 - Wiley Online Library
Purpose Gastrointestinal motion patterns such as peristalsis and segmental contractions can
alter the shape and position of the stomach and intestines with respect to other irradiated …

Estimating liver perfusion from free–breathing continuously acquired dynamic gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid–enhanced acquisition …

H Chandarana, TK Block, J Ream, A Mikheev… - Investigative …, 2015 - journals.lww.com
Objective The purpose of this study was to estimate perfusion metrics in healthy and cirrhotic
liver with pharmacokinetic modeling of high–temporal resolution reconstruction of …

[HTML][HTML] Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage

B Saha, S Pallatt, A Banerjee, AG Banerjee, R Pathak… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Highly conformal delivery of radiation therapy (RT) has revolutionized the treatment
landscape for primary and metastatic liver cancers, yet concerns persist regarding radiation …

Individualized adaptive radiation therapy allows for safe treatment of hepatocellular carcinoma in patients with Child-Turcotte-Pugh B liver disease

WC Jackson, M Tang, C Maurino… - International Journal of …, 2021 - Elsevier
Purpose Previous reports of stereotactic body radiation therapy (SBRT) for hepatocellular
carcinoma (HCC) suggest unacceptably high rates of toxicity in patients with Child-Turcotte …

Synthetic CT for MRI-based liver stereotactic body radiotherapy treatment planning

JS Bredfeldt, L Liu, M Feng, Y Cao… - Physics in Medicine & …, 2017 - iopscience.iop.org
A technique for generating MRI-derived synthetic CT volumes (MRCTs) is demonstrated in
support of adaptive liver stereotactic body radiation therapy (SBRT). Under IRB approval, 16 …