Chemistry of MRI contrast agents: current challenges and new frontiers
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …
performed annually around the world. The contrast agents, which improve diagnostic …
Applications for transition-metal chemistry in contrast-enhanced magnetic resonance imaging
Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …
Harnessing the properties of cobalt coordination complexes for biological application
AK Renfrew, ES O'Neill, TW Hambley… - Coordination Chemistry …, 2018 - Elsevier
Cobalt is an essential metal that is found in very low abundance in the body and the
environment. Cobalt coordination complexes exhibit interesting redox and magnetic …
environment. Cobalt coordination complexes exhibit interesting redox and magnetic …
Redox-Responsive MRI Probes Based on First-Row Transition-Metal Complexes
JR Morrow, JJ Raymond, MSI Chowdhury… - Inorganic …, 2022 - ACS Publications
The presence of multiple oxidation and spin states of first-row transition-metal complexes
facilitates the development of switchable MRI probes. Redox-responsive probes capitalize …
facilitates the development of switchable MRI probes. Redox-responsive probes capitalize …
Ratiometric pH Imaging with a CoII2 MRI Probe via CEST Effects of Opposing pH Dependences
AE Thorarinsdottir, K Du, JHP Collins… - Journal of the American …, 2017 - ACS Publications
We report a Co2-based magnetic resonance (MR) probe that enables the ratiometric
quantitation and imaging of pH through chemical exchange saturation transfer (CEST). This …
quantitation and imaging of pH through chemical exchange saturation transfer (CEST). This …
Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner
Purpose To demonstrate feasibility of developing a noninvasive extracellular pH (pHe)
mapping method on a clinical MRI scanner for molecular imaging of liver cancer. Methods In …
mapping method on a clinical MRI scanner for molecular imaging of liver cancer. Methods In …
Low-Spin Fe (III) Macrocyclic Complexes of Imidazole-Appended 1, 4, 7-Triazacyclononane as Paramagnetic Probes
Two macrocyclic complexes of 1, 4, 7-triazacyclononane (TACN), one with N-methyl
imidazole pendants,[Fe (Mim)] 3+, and one with unsubstituted NH imidazole pendants,[Fe …
imidazole pendants,[Fe (Mim)] 3+, and one with unsubstituted NH imidazole pendants,[Fe …
An Fe complex for 19 F magnetic resonance-based reversible redox sensing and multicolor imaging
We report a first-in-class responsive, pentafluorosulfanyl (–SF5)-tagged 19F MRI agent
capable of reversibly detecting reducing environments via an FeII/III redox couple. In the …
capable of reversibly detecting reducing environments via an FeII/III redox couple. In the …
Eight-Coordinate, Stable Fe(II) Complex as a Dual 19F and CEST Contrast Agent for Ratiometric pH Imaging
Accurate mapping of small changes in pH is essential to the diagnosis of diseases such as
cancer. The difficulty in mapping pH accurately in vivo resides in the need for the probe to …
cancer. The difficulty in mapping pH accurately in vivo resides in the need for the probe to …
Gear up for a pH shift: A responsive iron (II) 2-amino-6-picolyl-appended macrocyclic paracest agent that protonates at a pendent group
Two high-spin Fe (II) and Co (II) complexes of 1, 4, 7, 10-tetraazacyclododecane (CYCLEN)
appended with four 2-amino-6-picolyl groups, denoted as [Fe (TAPC)] 2+ and [Co (TAPC)] …
appended with four 2-amino-6-picolyl groups, denoted as [Fe (TAPC)] 2+ and [Co (TAPC)] …