A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Chimeric antigen receptor (CAR) therapy targeting CD19 is an effective treatment for
refractory B cell malignancies, especially acute lymphoblastic leukemia (ALL) 1. Although a …

Macrophages are innate immune cells that adopt diverse activation states in response to
their microenvironment. Editing macrophage activation to dampen inflammatory diseases by …

Cell death plays an important role during pathogen infections. Here, we report that interferon-
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …

Inefficient T cell migration is a major limitation of cancer immunotherapy. Targeted activation
of the tumor microenvironment may overcome this barrier. We demonstrate that neoadjuvant …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

In various diseases, there is an increased production of the free radicals needed to carry out
certain physiological processes but their excessive amounts can cause oxidative stress and …

This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

Amino acid metabolism is essential for cell survival, while the byproduct ammonia is toxic
and can injure cellular longevity. Here we show that CD8+ memory T (TM) cells mobilize the …