Sirtuin activators and inhibitors
JM Villalba, FJ Alcaín - Biofactors, 2012 - Wiley Online Library
Abstract Sirtuins 1‐7 (SIRT1‐7) belong to the third class of deacetylase enzymes, which are
dependent on NAD+ for activity. Sirtuins activity is linked to gene repression, metabolic …
dependent on NAD+ for activity. Sirtuins activity is linked to gene repression, metabolic …
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
AG Kazantsev, LM Thompson - Nature reviews Drug discovery, 2008 - nature.com
Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …
other important cellular proteins—have been recognized as potentially useful therapeutic …
Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications
Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal
muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two …
muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two …
Modeling human diseases in Caenorhabditis elegans
M Markaki, N Tavernarakis - Biotechnology journal, 2010 - Wiley Online Library
Genes linked to human diseases often function in evolutionarily conserved pathways, which
can be readily dissected in simple model organisms. Because of its short lifespan and well …
can be readily dissected in simple model organisms. Because of its short lifespan and well …
Histone deacetylases: Molecular mechanisms and therapeutic implications for muscular dystrophies
Histone deacetylases (HDACs) are enzymes that regulate the deacetylation of numerous
histone and non-histone proteins, thereby affecting a wide range of cellular processes …
histone and non-histone proteins, thereby affecting a wide range of cellular processes …
PABPN 1: molecular function and muscle disease
A Banerjee, LH Apponi, GK Pavlath… - The FEBS …, 2013 - Wiley Online Library
The polyadenosine RNA binding protein polyadenylate‐binding nuclear protein 1 (PABPN
1) plays key roles in post‐transcriptional processing of RNA. Although PABPN 1 is …
1) plays key roles in post‐transcriptional processing of RNA. Although PABPN 1 is …
Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans
A Vaccaro, A Tauffenberger, D Aggad, G Rouleau… - PloS one, 2012 - journals.plos.org
Mutations in the DNA/RNA binding proteins TDP-43 and FUS are associated with
Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Intracellular …
Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Intracellular …
[HTML][HTML] Automated drug screening with contractile muscle tissue engineered from dystrophic myoblasts
H Vandenburgh, J Shansky, F Benesch-Lee… - The FASEB …, 2009 - ncbi.nlm.nih.gov
Identification of factors that improve muscle function in boys with Duchenne muscular
dystrophy (DMD) could lead to an improved quality of life. To establish a functional in vitro …
dystrophy (DMD) could lead to an improved quality of life. To establish a functional in vitro …
Mechanisms and molecular probes of sirtuins
Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell
cycle, and apoptosis. Sirtuins are associated with a variety of age-associated diseases such …
cycle, and apoptosis. Sirtuins are associated with a variety of age-associated diseases such …
Sirtuin inhibitors
FJ Alcaín, JM Villalba - Expert opinion on therapeutic patents, 2009 - Taylor & Francis
Background: The sirtuin family of deacetylase enzymes comprises seven proteins (SIRT1-7)
that are dependent on NAD+ for their activity. Three proteins are located in the nucleus …
that are dependent on NAD+ for their activity. Three proteins are located in the nucleus …