The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Malformations of cortical development are a group of rare disorders commonly manifesting
with developmental delay, cerebral palsy or seizures. The neurological outcome is …

Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in
fetal abnormalities and microcephaly. However, information about the underlying molecular …

В руководстве представлены результаты 60-летней работы автора в области детской
и взрослой неврологии и эпилептологии. Впервые эпилептология представлена в …

Purpose: Focal cortical dysplasias (FCD) are localized regions of malformed cerebral cortex
and are very frequently associated with epilepsy in both children and adults. A broad …

Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …

De novo somatic mutations in focal areas are well documented in diseases such as
neoplasia but are rarely reported in malformation of the developing brain …

Neurodevelopment is a complex, dynamic process that involves a precisely orchestrated
sequence of genetic, environmental, biochemical, and physical events. Developmental …

Development of the human nervous system involves complex interactions among
fundamental cellular processes and requires a multitude of genes, many of which remain to …