The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use

KM Pfarr, AK Krome, I Al-Obaidi, H Batchelor… - Parasites & …, 2023 - Springer
In its 'Road map for neglected tropical diseases 2021–2030', the World Health Organization
outlined its targets for control and elimination of neglected tropical diseases (NTDs) and …

Current leishmaniasis drug discovery

AC Pinheiro, MVN de Souza - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition,
poor health services and unavailability of prophylactic control measures, neglected …

Photodynamic therapy for leishmaniasis: recent advances and future trends

M Varzandeh, R Mohammadinejad… - Photodiagnosis and …, 2021 - Elsevier
Leishmaniasis has infected more than 12 million people worldwide. This neglected tropical
disease, causing 20,000–30,000 deaths per year, is a global health problem. The …

The cytotoxic and anti-leishmanial activity of Oregano (Origanum vulgare) essential oil: An in vitro, in vivo, and in silico study

F Tomiotto-Pellissier, BT da Silva Bortoleti… - Industrial Crops and …, 2022 - Elsevier
This study was aimed at investigating the leishmanicidal and immunomodulatory of oregano
essential oil (OEO) from Origanum vulgare on experimental Leishmania amazonensis …

Exploring N-myristoyltransferase as a promising drug target against parasitic neglected tropical diseases

IJ dos Santos Nascimento, MAT Cavalcanti… - European Journal of …, 2023 - Elsevier
Neglected tropical diseases (NTDs) constitute a group of approximately 20 infectious
diseases that mainly affect the impoverished population without basic sanitation in tropical …

Mutual role of patients and the healthcare system in the control of cutaneous leishmaniasis

M Bamorovat, I Sharifi… - Transboundary and …, 2023 - Wiley Online Library
Leishmaniasis is a neglected and old emerging/reemerging disease that has extremely
increased and expanded in the different geographical areas. Cutaneous leishmaniasis (CL) …

Nanotechnology-aided diagnosis, treatment and prevention of leishmaniasis

O Kammona, E Tsanaktsidou - International Journal of Pharmaceutics, 2021 - Elsevier
Leishmaniasis is a prevalent parasitic infection belonging to neglected tropical diseases. It is
caused by Leishmania protozoan parasites transmitted by sandflies and it is responsible for …

In vitro and in vivo therapeutic potentials of 6-gingerol in combination with amphotericin B for treatment of Leishmania major infection: Powerful synergistic and …

A Keyhani, I Sharifi, E Salarkia, A Khosravi… - International …, 2021 - Elsevier
The ongoing conventional drugs for leishmaniasis treatment are insufficient. The present
study aimed to assess 6-gingerol alone and in combination with amphotericin B on …

Cutaneous/mucocutaneous leishmaniasis treatment for wound healing: classical versus new treatment approaches

P Severino, W Santana, ES Lisboa, VLS Santos… - Microbiology …, 2022 - mdpi.com
Cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (ML) show clinical
spectra that can range from a localized lesion (with a spontaneous healing process) to …

Cardiovascular effects of environmental metal antimony: redox dyshomeostasis as the key pathogenic driver

Y Tan, K El-Kersh, SE Watson… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Cardiovascular diseases (CVDs) are the leading cause of death worldwide,
which may be due to sedentary lifestyles with less physical activity and over nutrition as well …