The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …

Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to
secrete adequate levels of insulin. The molecular mechanisms underlying the progressive …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

Tissue sensitivity and response to exercise vary according to the time of day and alignment
of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not …

Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of
hundreds of molecules in biological samples with high sensitivity and molecular specificity …

Background Untargeted mass spectrometry (MS)-based metabolomics data often contain
missing values that reduce statistical power and can introduce bias in biomedical studies …

Mass spectrometry (MS) is the workhorse of metabolomics, proteomics and lipidomics. Mass
spectrometry imaging (MSI), its extension to spatially resolved analysis of tissues, is a …

Skeletal muscle myofibers are heterogeneous in their metabolism. However, metabolomic
profiling of single myofibers has remained difficult. Mass spectrometry imaging (MSI) is a …