Synthesis and applications of nitrogen-containing heterocycles as antiviral agents

TN Tran, M Henary - Molecules, 2022 - mdpi.com
Viruses have been a long-term source of infectious diseases that can lead to large-scale
infections and massive deaths. Especially with the recent highly contagious coronavirus …

N-Heterocycles as Promising Antiviral Agents: A Comprehensive Overview

G Ahmad, M Sohail, M Bilal, N Rasool, MU Qamar… - Molecules, 2024 - mdpi.com
Viruses are a real threat to every organism at any stage of life leading to extensive infections
and casualties. N-heterocycles can affect the viral life cycle at many points, including viral …

[PDF][PDF] Schiff bases as important class of pharmacological agents

ADA Sykula - Journal of Pharmacy and Pharmacology, 2018 - academia.edu
Therapeutics are compounds, which do not always exhibit healing powers. They sometimes
prevent or control roles. Many compounds, well known or less are treated as the therapeutic …

[HTML][HTML] Synthesis of pyrroles and condensed pyrroles as anti-inflammatory agents with multiple activities and their molecular docking study

MT Sarg, MM Koraa, AH Bayoumi… - Open Journal of …, 2015 - scirp.org
We herein disclose a series of novel pyrrole derivatives as well as fused pyrrolopyridines 6a,
b and 7a, b, pyrrolopyrazoles 8a, b, pyrrolo [2, 3-d] pyrimidine derivatives 10a-d, 12a, b, 14a …

A promising anti-cancer and anti-oxidant agents based on the pyrrole and fused pyrrole: synthesis, docking studies and biological evaluation

S Said Fatahala, E Ahmed Shalaby… - Anti-Cancer Agents …, 2015 - ingentaconnect.com
A series of N-aryl derivatives of pyrrole and its related derivatives of fused form (namely;
tetrahydroindole and dihydroindenopyrroles) were prepared in fair to good yields. The newly …

Novel pyrrole based triazole moiety as therapeutic hybrid: synthesis, characterization and anti-Alzheimer potential with molecular mechanism of protein ligand profile

S Khan, T Iqbal, MB Khan, R Hussain, Y Khan… - BMC chemistry, 2024 - Springer
As a springboard to explore novel potent inhibitors of cholinesterase enzymes (AChE and
BChE) responsible for causing Alzheimer disorder, the current study was conducted to …

Synthesis, molecular modelling and biological evaluation of novel pyrimidine derivatives as anti-inflammatory agents

NM Ahmed, S Nofal, SM Awad - Journal of Pharmaceutical …, 2020 - journal.send2sub.com
Aim: As part of ongoing studies in developing new anti-inflammatory agents, 2-thioxo-1, 2, 3,
4-tetrahydropyrimidine derivative 1 was synthesized by direct Biginelli condensation and …

An Efficient One-Pot Synthesis of 5-Sulfanyl-1-[2-(vinyloxy) ethyl]-1H-pyrrol-2-amines as Precursors of 1-Vinylpyrroles

OA Tarasova, NA Nedolya, AI Albanov… - Synthesis, 2022 - thieme-connect.com
Sequential processing of monolithiated tertiary propargylamines with 2-(vinyloxy) ethyl
isothiocyanate and t-BuOK–DMSO results in the introduction of a highly reactive 2-(vinyloxy) …

[PDF][PDF] Synthesis, Characterization, Molecular Docking, and in Vitro Screening of New Metal Complexes Derived from Acyclovir Schiff Base with Ciprofloxacin Ligand

SA Ahmed, SW Zedan - Iraqi Journal of Science, 2023 - iasj.net
In this work, combining acyclovir with ciprofloxacin (CCP), a new Schiff base and its metal
complexes with iron (III), manganese (II), copper (II), zinc (II), and calcium (II) ions are …

Synthesis of 1,3- and 1,2,3-functionalized pyrroles via Ir(I)-catalyzed vinylation of allyl alcohols

D Alavez-Rosas, M Maldonado-Domínguez… - Chemistry of …, 2017 - Springer
An efficient method for the preparation of 1, 3-disubstituted and 1, 2, 3-trisubstituted pyrroles
was developed through a sequence involving O-vinylation of allyl alcohols followed by …