Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the
adenomatous polyposis coli (APC) gene. Germline mutations cause familial adenomatous …

In Alzheimer's disease (AD) pathogenesis, increasing evidence implicates mitochondrial
dysfunction resulting from molecular defects in oxidative phosphorylation (OXPHOS). The …

Mutations in the adenomatous polyposis coli (APC) gene cause familial adenomatous
polyposis (FAP). Disease severity and the presence of extracolonic manifestations seem to …

Colon cancer closely follows the paradigm of a single “gatekeeper gene.” Mutations
inactivating the APC (adenomatous polyposis coli) gene are found in∼ 80% of all human …

Over the last decade, a subset of familial adenomatous polyposis (FAP) patients with a
milder course of disease termed attenuated familial adenomatous polyposis (AFAP) has …

Colorectal cancer is the third leading cause of cancer-related deaths in both men and
women in the United States and is estimated to have affected 148,000 people in 2002. The …

Germline intragenic mutations in PTEN are associated with 80% of patients with Cowden
syndrome (CS) and 60% of patients with Bannayan-Riley-Ruvalcaba syndrome (BRRS) …

The genes associated with each of the inherited syndromes of colon cancer have now been
identified, and genetic testing is available for diagnosis. These syndromes include familial …