Host-directed antiviral therapy

N Kumar, S Sharma, R Kumar, BN Tripathi… - Clinical microbiology …, 2020 - Am Soc Microbiol
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

Pathogenicity and virulence of influenza

Y Liang - Virulence, 2023 - Taylor & Francis
Influenza viruses, including four major types (A, B, C, and D), can cause mild-to-severe and
lethal diseases in humans and animals. Influenza viruses evolve rapidly through antigenic …

The NF-κB transcriptional footprint is essential for SARS-CoV-2 replication

BE Nilsson-Payant, S Uhl, A Grimont… - Journal of …, 2021 - Am Soc Microbiol
ABSTRACT SARS-CoV-2, the etiological agent of COVID-19, is characterized by a delay in
type I interferon (IFN-I)-mediated antiviral defenses alongside robust cytokine production …

Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus

L Josset, VD Menachery, LE Gralinski, S Agnihothram… - MBio, 2013 - Am Soc Microbiol
ABSTRACT A novel human coronavirus (HCoV-EMC) was recently identified in the Middle
East as the causative agent of a severe acute respiratory syndrome (SARS) resembling the …

The influenza virus polymerase complex: an update on its structure, functions, and significance for antiviral drug design

A Stevaert, L Naesens - Medicinal research reviews, 2016 - Wiley Online Library
Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

Antiviral strategies against influenza virus: towards new therapeutic approaches

A Loregian, B Mercorelli, G Nannetti… - Cellular and molecular …, 2014 - Springer
Influenza viruses are major human pathogens responsible for respiratory diseases affecting
millions of people worldwide and characterized by high morbidity and significant mortality …

PALMD regulates aortic valve calcification via altered glycolysis and NF-κB–mediated inflammation

S Wang, H Yu, J Gao, J Chen, P He, H Zhong… - Journal of Biological …, 2022 - ASBMB
Recent genome-wide association and transcriptome-wide association studies have
identified an association between the PALMD locus, encoding palmdelphin, a protein …

Promising antivirals for PLpro of SARS-CoV-2 using virtual screening, molecular docking, dynamics, and MMPBSA

R Kumari, V Kumar, P Dhankhar… - Journal of Biomolecular …, 2023 - Taylor & Francis
The recent pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection (COVID-19) is a viral respiratory disease that has been spread all over the globe …

[HTML][HTML] Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway

Y Ding, L Chen, W Wu, J Yang, Z Yang, S Liu - Microbes and infection, 2017 - Elsevier
Influenza viruses, the main cause of respiratory tract diseases, cause high morbidity and
mortality in humans. Excessive inflammation in the lungs is proposed to be a hallmark for the …

Influenza virus infections and cellular kinases

R Meineke, GF Rimmelzwaan, H Elbahesh - Viruses, 2019 - mdpi.com
Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for
yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs …