Three great plague pandemics, resulting in nearly 200 million deaths in human history and
usage as a biowarfare agent, have made Yersinia pestis as one of the most virulent human …

The potential application of Yersinia pestis for bioterrorism emphasizes the urgent need to
develop more effective vaccines against airborne infection. The current status of plague …

Pneumonic plague is one of the world's most deadly infectious diseases. The causative
bacterium, Yersinia pestis, has the potential to be exploited as a biological weapon, and no …

The etiologic agent of plague, Yersinia pestis, is a globally distributed pathogen which
poses both a natural and adversarial threat. Due largely to the rapid course and high …

Vaccination can significantly reduce worldwide morbidity and mortality to infectious
diseases, thereby reducing the health burden as a result of microbial infections. Effective …

YB designed and did the experiments with cells and mice, analyzed data, and contributed to
writing the manuscript; JZ designed the experiments with mice and contributed to …

Immunization with the Yersinia pestis F1 and LcrV proteins improves survival in mouse and
non-human primate models of pneumonic plague. F1-and LcrV-specific antibodies …

Septic pneumonias resulting from bacterial infections of the lung are a leading cause of
human death worldwide. Little is known about the capacity of CD8 T cell-mediated immunity …

Yersinia pestis is the causative agent of plague and is a re-emerging pathogen that also has
the potential as a biological weapon, necessitating the development of a preventive vaccine …

Yersinia pestis causes primary pneumonic plague in many mammalian species, including
humans, mice, and rats. Virulent Y. pestis strains undergo frequent spontaneous deletion of …