The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal
dominantly inherited progressive disorders, the clinical hallmark of which is loss of balance …

The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant
neurodegenerative disorders that present principally with progressive ataxia. Within the past …

Background Spinocerebellar ataxias are dominantly inherited neurodegenerative diseases.
As potential treatments for these diseases are being developed, precise knowledge of their …

Background Our previous study in patients with cerebellar ataxias of different causes
showed significant benefit of riluzole after 8 weeks. We aimed to confirm these results in …

The hereditary ataxias are a highly heterogeneous group of disorders phenotypically
characterized by gait ataxia, incoordination of eye movements, speech, and hand …

Objectives This study aimed to synthesize and evaluate published evidence on the
measurement properties of the EQ VAS, a component of all EQ-5D questionnaires. Methods …

Repeated sessions of cerebellar anodal transcranial direct current stimulation (tDCS) have
been suggested to modulate cerebellar-motor cortex (M1) connectivity and decrease ataxia …

Background We assessed the clinimetric properties of ataxia rating scales and functional
tests, and made recommendations regarding their use. Methods A systematic literature …

Summary Background The European Friedreich's Ataxia Consortium for Translational
Studies (EFACTS) is a prospective international registry investigating the natural history of …

Abstract Background All spinocerebellar ataxias (SCAs) are rare diseases. SCA1, 2, 3 and 6
are the four most common SCAs, all caused by expanded polyglutamine-coding CAG …