Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents,
and the 5-year event-free survival rate has not improved significantly in the past three …

Monoclonal antibodies targeting programmed cell death 1/programmed cell death ligand 1
(PD-1/PD-L1) immune checkpoints have improved the treatments of cancers. However, not …

Simple Summary Osteosarcoma (OS), the most common primary bone tumor, mainly affects
children and adolescents. Unfortunately, in some cases, the absence of response to …

Osteosarcoma (OS) is a primary malignant bone tumor that most commonly affects children,
adolescents, and young adults. Here, we comprehensively analyze genomic, epigenomic …

Osteosarcoma is the most common primary malignant bone tumor and is associated with a
high risk of recurrence and distant metastasis. Effective treatment for osteosarcoma …

Purpose There are some lines of evidence suggesting a potential role of immunotherapy for
treating patients with osteosarcomas. Patients and methods This was an open-label …

The immune microenvironment extensively participates in tumorigenesis as well as
progression in osteosarcoma (OS). However, the landscape and dynamics of immune cells …

Patients who are diagnosed with osteosarcoma (OS) today receive the same therapy that
patients have received over the last 4 decades. Extensive efforts to identify more effective or …

Background There are many types of therapies for cancer. In these days, immunotherapies,
especially immune checkpoint inhibitors, are focused on. Though many types of immune …