Glaucoma: the retina and beyond

BM Davis, L Crawley, M Pahlitzsch, F Javaid… - Acta …, 2016 - Springer
Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …

Spaceflight-induced intracranial hypertension and visual impairment: pathophysiology and countermeasures

LF Zhang, AR Hargens - Physiological reviews, 2018 - journals.physiology.org
Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained
major risk for future long-duration spaceflight. NASA recently redefined this syndrome as …

Discovery and clinical translation of novel glaucoma biomarkers

G Beykin, AM Norcia, VJ Srinivasan, A Dubra… - Progress in Retinal and …, 2021 - Elsevier
Glaucoma and other optic neuropathies are characterized by progressive dysfunction and
loss of retinal ganglion cells and their axons. Given the high prevalence of glaucoma-related …

Non-invasive intracranial pressure monitoring

SJ Müller, E Henkes, MJ Gounis, S Felber… - Journal of clinical …, 2023 - mdpi.com
(1) Background: Intracranial pressure (ICP) monitoring plays a key role in the treatment of
patients in intensive care units, as well as during long-term surgeries and interventions. The …

Facts and myths of cerebrospinal fluid pressure for the physiology of the eye

JB Jonas, N Wang, D Yang, R Ritch… - Progress in retinal and …, 2015 - Elsevier
The orbital cerebrospinal fluid pressure (CSFP) represents the true counter-pressure against
the intraocular pressure (IOP) across the lamina cribrosa and is, therefore, one of the two …

[HTML][HTML] Optic nerve sheath as a novel mechanical load on the globe in ocular duction

JL Demer - Investigative ophthalmology & visual science, 2016 - arvojournals.org
Purpose: The optic nerve (ON) sheath's role in limiting duction has been previously
unappreciated. This study employed magnetic resonance imaging (MRI) to demonstrate this …

Effects of short‐term mild hypercapnia during head‐down tilt on intracranial pressure and ocular structures in healthy human subjects

SS Laurie, G Vizzeri, G Taibbi, CR Ferguson… - Physiological …, 2017 - Wiley Online Library
Many astronauts experience ocular structural and functional changes during long‐duration
spaceflight, including choroidal folds, optic disc edema, globe flattening, optic nerve sheath …

Intracranial and intraocular pressure at the lamina cribrosa: gradient effects

G Jóhannesson, A Eklund, C Lindén - Current neurology and …, 2018 - Springer
Purpose of Review A pressure difference between the intraocular and intracranial
compartments at the site of the lamina cribrosa has been hypothesized to have a …

Finite element modeling of effects of tissue property variation on human optic nerve tethering during adduction

J Park, A Shin, JL Demer - Scientific reports, 2022 - nature.com
Tractional tethering by the optic nerve (ON) on the eye as it rotates towards the midline in
adduction is a significant ocular mechanical load and has been suggested as a cause of ON …

Magnetic resonance imaging of optic nerve traction during adduction in primary open-angle glaucoma with normal intraocular pressure

JL Demer, RA Clark, SY Suh… - … & visual science, 2017 - iovs.arvojournals.org
Purpose: We used magnetic resonance imaging (MRI) to ascertain effects of optic nerve
(ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle …