Perforin is a cytolytic mediator produced by killer lymphocytes, and is stored in and released
by cytoplasmic granules. The proteh is partiall, homologous to the terminal components of …

The immune system provides good models for cell death, a phenomenon now recognized to
be of fundamental importance in many fields of biology. Cell death is strikingly polymorphic …

T cells play an important role in the pathogenesis of diabetes in the nonobese diabetic
(NOD) mouse. CD8 cytotoxic T cell lines and clones were generated from the lymphocytic …

Protozoan parasite T. cruzi invades cells within acidic vacuoles, but shortly afterward
escapes into the cytosol. Exit from the phagosome is blocked by raising the pH of acidic …

Cytotoxic lymphocytes rapidly respond and destroy both malignant cells and cells infected
with intracellular pathogens. One mechanism, known as granule exocytosis, employs the …

Perforin, a pore-forming protein secreted by cytotoxic lymphocytes, is indispensable for
destroying virus-infected cells and for maintaining immune homeostasis. Perforin …

A pore-forming protein (PFP; perforin) and various serine esterases (SE) have been
identified in the cytoplasmic granules of CTL and NK cells. Perforin and several SE have …

Tumors”, Nature Medicine, 3 (6), pp. 682-685,(Jun. 1997). Pollok, KE, et al.,“4-1BBT-cell
antigen binds to mature B cells and macrophages, and costimulates anti-u-primed splenic B …

Complement C6 is one of five plasma proteins that are incorporated into the lytic terminal
complement complex on lipid membranes (C5b-9m) upon activation of the complement …

We have discussed in the previous sections the recent progress made toward elucidating
the regulatory mechanism of perforin gene transcription and the domain structure of the …