Thinking outside the box: non-canonical targets in multiple sclerosis
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease
Immune cell trafficking is a critical element of the intestinal immune response, both in
homeostasis and in pathological conditions associated with inflammatory bowel disease …
homeostasis and in pathological conditions associated with inflammatory bowel disease …
Ponesimod compared with teriflunomide in patients with relapsing multiple sclerosis in the active-comparator phase 3 OPTIMUM study: a randomized clinical trial
Importance To our knowledge, the Oral Ponesimod Versus Teriflunomide In Relapsing
Multiple Sclerosis (OPTIMUM) trial is the first phase 3 study comparing 2 oral disease …
Multiple Sclerosis (OPTIMUM) trial is the first phase 3 study comparing 2 oral disease …
Neuron-oligodendrocyte interactions in the structure and integrity of axons
The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …
Oligodendrocytes and axons have a reciprocal signaling relationship in which …
Targeting sphingosine-1-phosphate signaling in immune-mediated diseases: beyond multiple sclerosis
T Pérez-Jeldres, M Alvarez-Lobos, J Rivera-Nieves - Drugs, 2021 - Springer
Abstract Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions
by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in …
by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in …
Pre-clinical and clinical implications of “inside-out” vs.“outside-in” paradigms in multiple sclerosis etiopathogenesis
HE Titus, Y Chen, JR Podojil, AP Robinson… - Frontiers in cellular …, 2020 - frontiersin.org
Multiple Sclerosis (MS) is an immune-mediated neurological disorder, characterized by
central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and …
central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and …
Rocket‐Inspired Effervescent Motors for Oral Macromolecule Delivery
Oral administration is among the most convenient ways with good patient compliance for
drug delivery; while it remains a challenge to achieve desirable bioavailability of most …
drug delivery; while it remains a challenge to achieve desirable bioavailability of most …
Prosaposin mediates inflammation in atherosclerosis
MMT van Leent, TJ Beldman, YC Toner… - Science translational …, 2021 - science.org
Macrophages play a central role in the pathogenesis of atherosclerosis. The inflammatory
properties of these cells are dictated by their metabolism, of which the mechanistic target of …
properties of these cells are dictated by their metabolism, of which the mechanistic target of …
Decoding IL-23 signaling cascade for new therapeutic opportunities
G Pastor-Fernández, IR Mariblanca, MN Navarro - Cells, 2020 - mdpi.com
The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …
[HTML][HTML] Update on treatment in multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. In
recent years, many disease-modifying therapies (DMT) have been approved for MS …
recent years, many disease-modifying therapies (DMT) have been approved for MS …