Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases
Y Zhang, Y Lei, Y Dong, S Chen, S Sun, F Zhou… - Pharmacology & …, 2024 - Elsevier
RNA ac4C modification is a novel and rare chemical modification observed in mRNA.
Traditional biochemical studies had primarily associated ac4C modification with tRNA and …
Traditional biochemical studies had primarily associated ac4C modification with tRNA and …
ac4C RNA modification in Cancer: Unraveling Multifaceted Roles and Promising Therapeutic Horizons
W Ouyang, Z Huang, K Wan, T Nie, H Chen, H Yao - Cancer Letters, 2024 - Elsevier
RNA modifications play a crucial role in cancer development, profoundly influencing various
stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export …
stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export …
Chemotherapy-induced acetylation of ACLY by NAT10 promotes its nuclear accumulation and acetyl-CoA production to drive chemoresistance in hepatocellular …
Y Wang, K Su, C Wang, T Deng, X Liu, S Sun… - Cell Death & …, 2024 - nature.com
Chemotherapeutic efficacy is seriously impeded by chemoresistance in more than half of
hepatocellular carcinoma (HCC) patients. However, the mechanisms involved in …
hepatocellular carcinoma (HCC) patients. However, the mechanisms involved in …
N‐acetyltransferase 10 facilitates tumorigenesis of diffuse large B‐cell lymphoma by regulating AMPK/mTOR signalling through N4‐acetylcytidine modification of …
M Ding, Z Yu, T Lu, S Hu, X Zhou… - Clinical and …, 2024 - Wiley Online Library
Background Accumulating studies suggested that posttranscriptional modifications exert a
vital role in the tumorigenesis of diffuse large B‐cell lymphoma (DLBCL). N4‐acetylcytidine …
vital role in the tumorigenesis of diffuse large B‐cell lymphoma (DLBCL). N4‐acetylcytidine …
Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation
H Liu, L Xu, S Yue, H Su, X Chen, Q Liu… - Cancer …, 2024 - Wiley Online Library
Abstract Background N4‐acetylcytidine (ac4C) represents a novel messenger RNA (mRNA)
modification, and its associated acetyltransferase N‐acetyltransferase 10 (NAT10) plays a …
modification, and its associated acetyltransferase N‐acetyltransferase 10 (NAT10) plays a …
[HTML][HTML] An extended wave of global mRNA deadenylation sets up a switch in translation regulation across the mammalian oocyte-to-embryo transition
K Lee, K Cho, R Morey, H Cook-Andersen - Cell reports, 2024 - cell.com
Without new transcription, gene expression across the oocyte-to-embryo transition (OET)
relies instead on regulation of mRNA poly (A) tails to control translation. However, how tail …
relies instead on regulation of mRNA poly (A) tails to control translation. However, how tail …
Loss of NAT10 Reduces the Translation of Kmt5a mRNA Through ac4C Modification in Cardiomyocytes and Induces Heart Failure
T Xu, T Du, X Zhuang, X He, Y Yan, J Wu… - Journal of the …, 2024 - ahajournals.org
Background In the past decade, the biological functions of various RNA modifications in
mammals have been uncovered. N4‐acetylcytidine (ac4C), a highly conserved RNA …
mammals have been uncovered. N4‐acetylcytidine (ac4C), a highly conserved RNA …
N4-acetylcytidine of Nop2 mRNA is required for the transition of morula-to-blastocyst
M Wang, R Cheng, H He, Z Han, Y Zhang… - Cellular and Molecular …, 2023 - Springer
Abstract N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) modification is
crucial for mRNA stability and translation efficiency, yet the underlying function in …
crucial for mRNA stability and translation efficiency, yet the underlying function in …
[HTML][HTML] NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway
R Yang, W Yu, L Lin, Z Cui, J Tang, G Li, M Jin… - Journal of Advanced …, 2024 - Elsevier
Introduction Excessive osteoclastogenesis is a key driver of inflammatory bone loss.
Suppressing osteoclastogenesis has always been considered essential for the treatment of …
Suppressing osteoclastogenesis has always been considered essential for the treatment of …
N-acetyltransferase 10 is implicated in the pathogenesis of cycling T cell-mediated autoimmune and inflammatory disorders in mice
W Li, X Mao, J Xie, J Li, B Liu, L Wu, B Yang… - Nature …, 2024 - nature.com
T cell expansion has a crucial function in both autoimmune and chronic inflammatory
diseases, with cycling T cells contributing to the pathogenesis of autoimmune diseases by …
diseases, with cycling T cells contributing to the pathogenesis of autoimmune diseases by …