Current understanding of biological interactions and processing of dna origami nanostructures: role of machine learning and implications in drug delivery

M Singh, D Sharma, M Garg, A Kumar, A Baliyan… - Biotechnology …, 2022 - Elsevier
DNA origami has emerged as an exciting avenue that provides a versatile two and three-
dimensional DNA-based platform for nanomedicine and drug delivery applications. Their …

Self-assembly of DNA origami for nanofabrication, biosensing, drug delivery, and computational storage

Z He, K Shi, J Li, J Chao - Iscience, 2023 - cell.com
Since the pioneering work of immobile DNA Holliday junction by Ned Seeman in the early
1980s, the past few decades have witnessed the development of DNA nanotechnology. In …

Bioorthogonal disassembly of hierarchical DNAzyme nanogel for high-performance intracellular microRNA imaging

J Shang, S Yu, R Li, Y He, Y Wang, F Wang - Nano Letters, 2023 - ACS Publications
Rolling circle amplification (RCA) enables the facile construction of compact and versatile
DNA nanoassemblies which are yet rarely explored for intracellular analysis. This is might …

Economical routes to size-specific assembly of self-closing structures

TE Videbæk, D Hayakawa, GM Grason, MF Hagan… - Science …, 2024 - science.org
Programmable self-assembly has seen an explosion in the diversity of synthetic crystalline
materials, but developing strategies that target “self-limiting” assemblies has remained a …

NIR/pH-triggered aptamer-functionalized DNA origami nanovehicle for imaging-guided chemo-phototherapy

M Li, G Yang, Y Zheng, J Lv, W Zhou, H Zhang… - Journal of …, 2023 - Springer
Targeted chemo-phototherapy has received widespread attention in cancer treatment for its
advantages in reducing the side effects of chemotherapeutics and improving therapeutic …

Isothermal self-assembly of multicomponent and evolutive DNA nanostructures

C Rossi-Gendron, F El Fakih, L Bourdon… - Nature …, 2023 - nature.com
Thermal annealing is usually needed to direct the assembly of multiple complementary DNA
strands into desired entities. We show that, with a magnesium-free buffer containing NaCl …

Advancing the utility of DNA origami technique through enhanced stability of DNA-origami-based assemblies

S Manuguri, MK Nguyen, J Loo… - Bioconjugate …, 2022 - ACS Publications
Since its discovery in 2006, the DNA origami technique has revolutionized bottom-up
nanofabrication. This technique is simple yet versatile and enables the fabrication of …

A stable DNA Tetrahedra–AuNCs nanohybrid: On-site programmed disassembly for tumor imaging and combination therapy

H Sun, T Wang, W Ma, J Huang, B Chen, H Cheng… - Biomaterials, 2022 - Elsevier
Despite DNA nanotechnology has spawned a broad variety and taken a giant leap toward
cancer theranostic applications over the last decade, the homogeneous DNA nanostructures …

Investigation and Regulation of DNA Nanostructures on Activating cGAS‐STING Signaling

K Zou, P Zhang, Y Wang, Y Liu, B Ji, P Zhan… - Small …, 2024 - Wiley Online Library
DNA nanostructures have shown great potential in biomedical fields. However, the immune
responses, especially the activation of the cGAS‐STING signaling (A‐cGSs), induced by …

Controlled mechanochemical coupling of anti-junctions in DNA origami arrays

F Cole, M Pfeiffer, D Wang, T Schröder, Y Ke… - Nature …, 2024 - nature.com
Allostery is a hallmark of cellular function and important in every biological system. Still, we
are only starting to mimic it in the laboratory. Here, we introduce an approach to study …