Organocatalytic atroposelective synthesis of indole derivatives bearing axial chirality: strategies and applications

HH Zhang, F Shi - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Catalytic atroposelective syntheses of axially chiral compounds have stimulated
extensive interest in multiple communities, such as synthetic chemistry, biochemistry, and …

Recent advances in catalytic asymmetric construction of atropisomers

JK Cheng, SH Xiang, S Li, L Ye, B Tan - Chemical Reviews, 2021 - ACS Publications
Atropisomerism is a stereochemical behavior portrayed by three-dimensional molecules that
bear rotationally restricted σ bond. Akin to the well-represented point-chiral molecules …

Stereodynamic strategies to induce and enrich chirality of atropisomers at a late stage

CB Roos, CH Chiang, LAM Murray, D Yang… - Chemical …, 2023 - ACS Publications
Enantiomers, where chirality arises from restricted rotation around a single bond, are
atropisomers. Due to the unique nature of the origins of their chirality, synthetic strategies to …

Atroposelective transformation of axially chiral (hetero) biaryls. From desymmetrization to modern resolution strategies

JA Carmona, C Rodríguez-Franco… - Chemical Society …, 2021 - pubs.rsc.org
This tutorial review provides a systematic overview of the available methodologies for the
atroposelective transformation of (heterobiaryl) biaryl precursors toward the synthesis of …

Organocatalytic atroposelective synthesis of N− N axially chiral indoles and pyrroles by de novo ring formation

KW Chen, ZH Chen, S Yang, SF Wu… - Angewandte Chemie …, 2022 - Wiley Online Library
The first highly atroposelective construction of N− N axially chiral indole scaffolds was
established via a new strategy of de novo ring formation. This strategy makes use of the …

Catalytic Asymmetric Synthesis of Axially Chiral 3, 3'‐Bisindoles by Direct Coupling of Indole Rings

FT Sheng, S Yang, SF Wu, YC Zhang… - Chinese Journal of …, 2022 - Wiley Online Library
Comprehensive Summary A new strategy for the enantioselective synthesis of axially chiral
3, 3'‐bisindoles was devised by the direct coupling of two indole rings. This strategy makes …

Construction of CB axial chirality via dynamic kinetic asymmetric cross-coupling mediated by tetracoordinate boron

K Yang, Y Mao, Z Zhang, J Xu, H Wang, Y He… - Nature …, 2023 - nature.com
Catalytic dynamic kinetic asymmetric transformation (DyKAT) provides a powerful tool to
access chiral stereoisomers from racemic substrates. Such transformation has been widely …

Catalytic asymmetric synthesis of atropisomers bearing multiple chiral elements: an emerging field

HH Zhang, TZ Li, SJ Liu, F Shi - Angewandte Chemie, 2024 - Wiley Online Library
With the rapid development of asymmetric catalysis, the demand for the enantioselective
synthesis of complex and diverse molecules with different chiral elements is increasing …

Rhodium-catalyzed atroposelective oxidative C–H/C–H cross-coupling reaction of 1-aryl isoquinoline derivatives with electron-rich heteroarenes

Q Wang, WW Zhang, H Song, J Wang… - Journal of the …, 2020 - ACS Publications
Rhodium (III)-catalyzed enantioselective oxidative C–H/C–H cross-coupling reaction
between two arenes is disclosed. With the combination of a chiral CpRh (III) complex and a …

A bulky chiral N-heterocyclic carbene palladium catalyst enables highly enantioselective Suzuki–Miyaura cross-coupling reactions for the synthesis of biaryl …

D Shen, Y Xu, SL Shi - Journal of the American Chemical Society, 2019 - ACS Publications
Axially chiral biaryl scaffolds are essential structural units in chemistry. The asymmetric Pd-
catalyzed Suzuki–Miyaura cross-coupling reaction has been widely recognized as one of …