Cancer-testis antigens are tumor antigens that their expression is almost limited to male
germ cells in the TESTIS. Some of CANCER-testis antigens are also expressed in the ovary …

Signal perception is a key function in regulating biological activities and adapting to
changing environments. Per-Arnt-Sim (PAS) domains are ubiquitous sensors found in …

Multiple myeloma (MM) is a life‐threatening haematological malignancy for which standard
therapy is inadequate. Autologous stem cell transplantation is a relatively effective treatment …

Background In multiple myeloma, expression of cancer testis antigens may provide
prognostic markers and potential targets for immunotherapy. Expression at relapse has not …

Abstract Cancer-testis (CT) antigens/genes show restricted expression in normal tissues but
widespread expression in many tumour types. This, coupled with their ability to induce …

The OX‐TES‐4 antigen originally elicited an antibody response in 50% of diffuse large B‐
cell lymphoma (DLBCL) patients but not in control subjects. OX‐TES‐4 is encoded by a …

Dendritic cell (DC) immunotherapy is being actively studied in multiple myeloma (MM). We
aimed to use positron emission tomography or single positron emission tomography to …

Despite advances in defining clinically relevant subtypes of diffuse large B-cell lymphoma
(DLBCL), identifying high-risk patients and improved therapeutic options remains a priority …

The identification of immunogenic cancer testis antigens (CTAs) as immunotherapeutic
targets represents one approach to improve treatment options for diffuse large B‐cell …

Results: Several CTAs including NY-ESO-1, MAGE and GAGE family have been shown to
be expressed in MM patients. Cellular and humoral immune responses against these …