The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …

Platelets are chief effector cells in hemostasis. In addition, they are multifaceted
inflammatory cells with functions that span the continuum from innate immune responses to …

Platelets are anucleated blood elements highly potent at generating extracellular vesicles
(EVs) called microparticles (MPs). Whereas EVs are accepted as an important means of …

Platelets are among the most abundant cells in the mammalian circulation. Classical platelet
functions in hemostasis and wound healing have been intensively explored and are …

Platelets are small cellular fragments with the primary physiological role of maintaining
hemostasis. In addition to this well-described classical function, it is becoming increasingly …

While platelet function has traditionally been described in the context of maintaining
vascular integrity, recent evidence suggests that platelets can modulate inflammation in a …

Biological discovery has been driven by advances in throughput and resolution of analysis
technologies. They have also created an indelible bias for snapshot-based knowledge …

Platelets are hematopoietic cells whose main function has for a long time been considered
to be the maintenance of vascular integrity. They have an essential role in the hemostatic …

In humans, blood Classical CD14+ monocytes contribute to host defense by secreting large
amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation …