Getting a molecular grip on the half-lives of iminothioindoxyl photoswitches

ME Boëtius, MWH Hoorens, M Ošťadnický… - Chemical …, 2024 - pubs.rsc.org
Visible-light-operated photoswitches are of growing interest in reversibly controlling
molecular processes, enabling for example the precise spatiotemporal focusing of drug …

Novel, unifying mechanism for aromatic primary-amines (therapeutics, carcinogens and toxins): electron transfer, reactive oxygen species, oxidative stress and …

P Kovacic, R Somanathan - MedChemComm, 2011 - pubs.rsc.org
Aromatic primary-amines (APAs) display physiological activity in various areas, including
therapeutics, carcinogens and toxicants. More familiar examples include aniline and …

Evaluating metabolite-related DNA oxidation and adduct damage from aryl amines using a microfluidic ECL array

I Bist, S Bhakta, D Jiang, TE Keyes, A Martin… - Analytical …, 2017 - ACS Publications
Damage to DNA from the metabolites of drugs and pollutants constitutes a major human
toxicity pathway known as genotoxicity. Metabolites can react with metal ions and NADPH to …

Immunohistochemistry of γ‐H2AX as a method of early detection of urinary bladder carcinogenicity in mice

M Sone, T Toyoda, YM Cho, J Akagi… - Journal of Applied …, 2019 - Wiley Online Library
Phosphorylated histone H2AX (γ‐H2AX) has been demonstrated as a DNA damage marker
both in vitro and in vivo. We previously reported the effects of genotoxic carcinogens in the …

Formation, Persistence, and Identification of DNA Adducts Formed by the Carcinogenic Environmental Pollutant o-Anisidine in Rats

K Naiman, M Dračínský, P Hodek… - Toxicological …, 2012 - academic.oup.com
Methoxyaniline (o-anisidine) is an industrial and environmental pollutant causing tumors of
urinary bladder in rodents. Here, we investigated the formation and persistence of DNA …

Human cytochrome-P450 enzymes metabolize N-(2-methoxyphenyl) hydroxylamine, a metabolite of the carcinogens o-anisidine and o-nitroanisole, thereby dictating …

K Naiman, M Martínková, HH Schmeiser, E Frei… - … /Genetic Toxicology and …, 2011 - Elsevier
N-(2-Methoxyphenyl) hydroxylamine is a component in the human metabolism of two
industrial and environmental pollutants and bladder carcinogens, viz. 2-methoxyaniline (o …

Stereoselective degradation of metalaxyl and its enantiomers in rat and rabbit hepatic microsomes in vitro

P Zhang, Z Shen, X Xu, W Zhu, Z Dang, X Wang… - Xenobiotica, 2012 - Taylor & Francis
The stereoselective degradations of racemate metalaxyl (rac-MX) and its single enantiomers
in rat and rabbit hepatic microsomes were assayed by a chiral high-performance liquid …

[PDF][PDF] Biomonitoring of human exposure to arylamines

E Richter - Front. Biosci, 2015 - article.imrpress.com
Introduction 3. Carcinogenic potential of o-toluidine 4. Human biomonitoring of arylamines
4.1. Biomonitoring of o-toluidine 4.1. 1. Urine and other body fluids 4.2. 2. Hemoglobin …

[PDF][PDF] Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens-anisidine and 2-nitroanisole follow from adducts generated by …

M Stiborová, K Naiman, M Martínková… - Interdisciplinary …, 2009 - sciendo.com
An aromatic amine, o-anisidine (2-methoxyaniline) and its oxidative counterpart, 2-
nitroanisole (2-methoxynitrobenzene), are the industrial and environmental pollutants …

[PDF][PDF] Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl) hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o …

K Naiman, E Frei, M Stiborova - Neuroendocrinology Letters, 2010 - nel.edu
Abstract OBJECTIVES: N-(2-methoxyphenyl) hydroxylamine is a human metabolite of two
industrial and environmental pollutants and bladder carcinogens 2-methoxyaniline (o …