P Kovacic, R Somanathan - MedChemComm, 2011 - pubs.rsc.org
Aromatic primary-amines (APAs) display physiological activity in various areas, including therapeutics, carcinogens and toxicants. More familiar examples include aniline and …
Damage to DNA from the metabolites of drugs and pollutants constitutes a major human toxicity pathway known as genotoxicity. Metabolites can react with metal ions and NADPH to …
M Sone, T Toyoda, YM Cho, J Akagi… - Journal of Applied …, 2019 - Wiley Online Library
Phosphorylated histone H2AX (γ‐H2AX) has been demonstrated as a DNA damage marker both in vitro and in vivo. We previously reported the effects of genotoxic carcinogens in the …
K Naiman, M Dračínský, P Hodek… - Toxicological …, 2012 - academic.oup.com
Methoxyaniline (o-anisidine) is an industrial and environmental pollutant causing tumors of urinary bladder in rodents. Here, we investigated the formation and persistence of DNA …
K Naiman, M Martínková, HH Schmeiser, E Frei… - … /Genetic Toxicology and …, 2011 - Elsevier
N-(2-Methoxyphenyl) hydroxylamine is a component in the human metabolism of two industrial and environmental pollutants and bladder carcinogens, viz. 2-methoxyaniline (o …
P Zhang, Z Shen, X Xu, W Zhu, Z Dang, X Wang… - Xenobiotica, 2012 - Taylor & Francis
The stereoselective degradations of racemate metalaxyl (rac-MX) and its single enantiomers in rat and rabbit hepatic microsomes were assayed by a chiral high-performance liquid …
E Richter - Front. Biosci, 2015 - article.imrpress.com
Introduction 3. Carcinogenic potential of o-toluidine 4. Human biomonitoring of arylamines 4.1. Biomonitoring of o-toluidine 4.1. 1. Urine and other body fluids 4.2. 2. Hemoglobin …
M Stiborová, K Naiman, M Martínková… - Interdisciplinary …, 2009 - sciendo.com
An aromatic amine, o-anisidine (2-methoxyaniline) and its oxidative counterpart, 2- nitroanisole (2-methoxynitrobenzene), are the industrial and environmental pollutants …
K Naiman, E Frei, M Stiborova - Neuroendocrinology Letters, 2010 - nel.edu
Abstract OBJECTIVES: N-(2-methoxyphenyl) hydroxylamine is a human metabolite of two industrial and environmental pollutants and bladder carcinogens 2-methoxyaniline (o …