Immunomodulation by enteric viruses

L Bernard-Raichon, K Cadwell - Annual Review of Virology, 2023 - annualreviews.org
Enteric viruses display intricate adaptations to the host mucosal immune system to
successfully reproduce in the gastrointestinal tract and cause maladies ranging from …

IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus

H Ingle, H Makimaa, S Aggarwal, H Deng, L Foster… - Science …, 2023 - science.org
Norovirus is a leading cause of epidemic viral gastroenteritis, with no currently approved
vaccines or antivirals. Murine norovirus (MNoV) is a well-characterized model of norovirus …

Systemic Immune Modulation by Gastrointestinal Nematodes

DN Kasal, L Warner, A Bryant… - Annual Review of …, 2024 - annualreviews.org
Gastrointestinal nematode (GIN) infection has applied significant evolutionary pressure to
the mammalian immune system and remains a global economic and human health burden …

HDAC3 integrates TGF-β and microbial cues to program tuft cell biogenesis and diurnal rhythms in mucosal immune surveillance

J Zhang, G Wang, J Ma, Y Duan, SA Sharma… - Science …, 2024 - science.org
The intestinal mucosal surface is directly exposed to daily fluctuations in food and microbes
driven by 24-hour light and feeding cycles. Intestinal epithelial tuft cells are key sentinels that …

Intestinal tuft cell immune privilege enables norovirus persistence

MS Strine, E Fagerberg, PW Darcy, GM Barrón… - Science …, 2024 - science.org
The persistent murine norovirus strain MNVCR6 is a model for human norovirus and enteric
viral persistence. MNVCR6 causes chronic infection by directly infecting intestinal tuft cells …

Amino acid substitutions in norovirus VP1 dictate host dissemination via variations in cellular attachment

JT Mills, SC Minogue, JS Snowden… - Journal of …, 2023 - Am Soc Microbiol
Viruses interact with receptors on the cell surface to initiate and coordinate infection. The
distribution of receptors on host cells can be a key determinant of viral tropism and host …

Murine norovirus: additional protocols for basic and antiviral studies

CE Wobus, AM Peiper, AM McSweeney… - Current …, 2023 - Wiley Online Library
Murine norovirus (MNV) is a positive‐sense, plus‐stranded RNA virus in the Caliciviridae
family. Viruses in this family replicate in the intestine and are transmitted by the fecal‐oral …

Tuft cells in the intestine, immunity and beyond

X Feng, P Flüchter, JC De Tenorio… - Nature Reviews …, 2024 - nature.com
Tuft cells have gained substantial attention over the past 10 years due to numerous reports
linking them with type 2 immunity and microorganism-sensing capacity in many mucosal …

Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

S Aggarwal, FC Walker, JS Weagley… - PLoS …, 2024 - journals.plos.org
Noroviruses (NoVs) are a leading cause of viral gastroenteritis. Despite global clinical
relevance, our understanding of how host factors, such as antiviral cytokines interferons …

TREM-1 as a Potential Coreceptor in Norovirus Pathogenesis: Insights from Transcriptomic Analysis and Molecular Docking

MTC Colmenares, AO Matos, PHS Dantas… - ACS …, 2025 - ACS Publications
Norovirus (NoV) is a major cause of acute diarrheal disease in humans. However, due to
complications in cultivating this virus, bioinformatics aids in elucidating the virus–host …